H-Ala-Arg-Arg-Cys-Tyr-Asn-Asp-Pro-Lys-Cys-Cys(Acm)-Asp-Phe-OH

Base Information

• Chemical Name: H-Ala-Arg-Arg-Cys-Tyr-Asn-Asp-Pro-Lys-Cys-Cys(Acm)-Asp-Phe-OH
• CAS No.: 1191395-92-2
• Molecular Formula: C₆₈H₁₀₄N₂₂O₂₁S₃
• Molecular Weight: 1661.91
• Mol file: 1191395-92-2.mol

Synonyms:H-Ala-Arg-Arg-Cys-Tyr-Asn-Asp-Pro-Lys-Cys-Cys(Acm)-Asp-Phe-OH

Chemical Property of H-Ala-Arg-Arg-Cys-Tyr-Asn-Asp-Pro-Lys-Cys-Cys(Acm)-Asp-Phe-OH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-Ala-Arg-Arg-Cys-Tyr-Asn-Asp-Pro-Lys-Cys-Cys(Acm)-Asp-Phe-OH

There total 1 articles about H-Ala-Arg-Arg-Cys-Tyr-Asn-Asp-Pro-Lys-Cys-Cys(Acm)-Asp-Phe-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

C41H45N7O7S (133805-16-0) + C32H28NO5Pol + C27H25N5O5S (117830-91-8) + C43H34N4O4S (1350610-96-6) + Fmoc-Asn(Trt)-OBt + Fmoc-Ala-benzotriazolyl ester (131124-64-6,124007-50-7) + (S)-6-tert-Butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid benzotriazol-1-yl ester (127485-55-6) + Fmoc-Asp(OtBu)-OBt (117830-90-7) + Fmoc-Pro-OBt + 3-(4-tert-butoxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid benzotriazol-1-yl ester (105916-78-7) → H-Ala-Arg-Arg-Cys-Tyr-Asn-Asp-Pro-Lys-Cys-Cys(Acm)-Asp-Phe-OH (1191395-92-2)

Guidance literature:

C₃₂H₂₈NO₅Pol; With piperidine; In 1-methyl-pyrrolidin-2-one; for 0.333333h; Automated synthesizer; solid phase reaction;

Fmoc-Asp(OtBu)-OBt; In 1-methyl-pyrrolidin-2-one; for 1.16667h; Automated synthesizer; solid phase reaction;

C₄₁H₄₅N₇O₇S; C₂₇H₂₅N₅O₅S; C₄₃H₃₄N₄O₄S; Fmoc-Asn(Trt)-OBt; Fmoc-Ala-benzotriazolyl ester; (S)-6-tert-Butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid benzotriazol-1-yl ester; Fmoc-Asp(OtBu)-OBt; Fmoc-Pro-OBt; 3-(4-tert-butoxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid benzotriazol-1-yl ester; Further stages;

DOI:10.1134/S1068162009030029

Reference yield: 94.7%

H-Ala-Arg-Arg-Cys-Tyr-Asn-Asp-Pro-Lys-Cys-Cys(Acm)-Asp-Phe-OH (1191395-92-2) → H-Ala-Arg-Arg-cyclo-(Cys-Tyr-Asn-Asp-Pro-Lys-Cys)-Cys(Acm)-Asp-Phe-OH (1191395-95-5)

Guidance literature:

With ammonium hydroxide; dihydrogen peroxide; In 1,4-dioxane; water; at 20 ℃; for 0.166667h; pH=8;

DOI:10.1134/S1068162009030029

Reference yield: 90.0%

H-Ala-Arg-Arg-Cys-Tyr-Asn-Asp-Pro-Lys-Cys-Cys(Acm)-Asp-Phe-OH (1191395-92-2) → H-Ala-Arg-Arg-Cys-Tyr-Asn-Asp-Pro-Lys-Cys-Cys-Asp-Phe-OH (1157845-78-7)

Guidance literature:

H-Ala-Arg-Arg-Cys-Tyr-Asn-Asp-Pro-Lys-Cys-Cys(Acm)-Asp-Phe-OH; With mercury(II) diacetate; water; acetic acid; at 20 ℃; for 1.5h;

With hydrogen sulfide; In water; for 0.5h;

DOI:10.1134/S1068162009030029

upstream raw materials:

C₄₁H₄₅N₇O₇S

C₂₇H₂₅N₅O₅S

C₄₃H₃₄N₄O₄S

Fmoc-Ala-benzotriazolyl ester

Downstream raw materials:

H-Ala-Arg-Arg-Cys-Tyr-Asn-Asp-Pro-Lys-Cys-Cys-Asp-Phe-OH

H-Ala-Arg-Arg-cyclo-(Cys-Tyr-Asn-Asp-Pro-Lys-Cys)-Cys(Acm)-Asp-Phe-OH