(E)-(3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-oct-6-enal

Base Information

Chemical Name:(E)-(3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-oct-6-enal
CAS No.:365217-63-6
Molecular Formula:C₂₄H₄₀O₄Si
Molecular Weight:420.665
Hs Code.:

Synonyms:(E)-(3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-oct-6-enal

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Chemical Property of (E)-(3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-oct-6-enal

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Technology Process of (E)-(3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-oct-6-enal

There total 5 articles about (E)-(3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-oct-6-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 365217-79-4
(E)-(3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-oct-6-en-1-ol

: 365217-63-6
(E)-(3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-oct-6-enal

Guidance literature:: With pyridine; Dess-Martin periodane; tert-butyl alcohol; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jo010249e

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 365217-63-6
(E)-(3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-oct-6-enal

Guidance literature:: Multi-step reaction with 3 steps

1: 1.6 g / PPTS / CH₂Cl₂ / 12 h

2: 90 percent / DIBAL / CH₂Cl₂ / 1.33 h / -78 - 0 °C

3: 90 percent / Dess-Martin periodinane; pyridine; t-BuOH / CH₂Cl₂ / 1 h / 20 °C

With pyridine; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; Dess-Martin periodane; tert-butyl alcohol; In dichloromethane; 3: Dess-Martin oxidation;
DOI:10.1021/jo010249e

Reference yield:

: {3-[(E)-(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1,1-dimethyl-pent-3-enyl]-oxiranyl}-methanol

: 365217-63-6
(E)-(3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-oct-6-enal

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / Red-Al / tetrahydrofuran; toluene / 60 h / -20 - 0 °C

2: 1.6 g / PPTS / CH₂Cl₂ / 12 h

3: 90 percent / DIBAL / CH₂Cl₂ / 1.33 h / -78 - 0 °C

4: 90 percent / Dess-Martin periodinane; pyridine; t-BuOH / CH₂Cl₂ / 1 h / 20 °C

With pyridine; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; Dess-Martin periodane; sodium bis(2-methoxyethoxy)aluminium dihydride; tert-butyl alcohol; In tetrahydrofuran; dichloromethane; toluene; 4: Dess-Martin oxidation;
DOI:10.1021/jo010249e