diethyl N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate

Base Information

Chemical Name:diethyl N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate
CAS No.:85828-54-2
Molecular Formula:C₂₃H₂₇N₅O₇
Molecular Weight:485.497
Hs Code.:

Synonyms:diethyl N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate

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Chemical Property of diethyl N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate

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Technology Process of diethyl N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate

There total 9 articles about diethyl N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 56830-58-1
2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

: 85828-53-1
diethyl N--L-glutamate

: 85828-54-2
diethyl N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate

Guidance literature:: With magnesium oxide; In methanol; for 3h; Heating;
DOI:10.1021/jm00362a015

Reference yield:

: 1075-49-6
4-ethenylbenzoic acid

: 85828-54-2
diethyl N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) DMF, 15 min, 2.) DMF, 25 deg C, 18 h

2: m-chloroperbenzoic acid / CHCl₃ / 72 h / 25 °C

3: 75 percent / HBr / CH₂Cl₂ / 0.33 h

4: 92.6 percent / Jones reagent / acetone / 0.33 h

5: 96 percent / HOAc, Zn / 1 h

6: SOCl₂ / benzene / 1.5 h / Heating

7: 1.) SOCl₂, 3.) HBr

8: 30 percent / magnesium oxide / methanol / 3 h / Heating

With 4-methyl-morpholine; thionyl chloride; jones reagent; hydrogen bromide; magnesium oxide; acetic acid; 3-chloro-benzenecarboperoxoic acid; zinc; isobutyl chloroformate; In methanol; dichloromethane; chloroform; acetone; benzene;
DOI:10.1021/jm00362a015

Reference yield:

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 85828-54-2
diethyl N-<<(2-amino-4-hydroxy-7,8-dihydro-8-oxa-6-pteridinyl)methyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) DMF, 15 min, 2.) DMF, 25 deg C, 18 h

2: m-chloroperbenzoic acid / CHCl₃ / 72 h / 25 °C

3: 75 percent / HBr / CH₂Cl₂ / 0.33 h

4: 92.6 percent / Jones reagent / acetone / 0.33 h

5: 96 percent / HOAc, Zn / 1 h

6: SOCl₂ / benzene / 1.5 h / Heating

7: 1.) SOCl₂, 3.) HBr

8: 30 percent / magnesium oxide / methanol / 3 h / Heating

With 4-methyl-morpholine; thionyl chloride; jones reagent; hydrogen bromide; magnesium oxide; acetic acid; 3-chloro-benzenecarboperoxoic acid; zinc; isobutyl chloroformate; In methanol; dichloromethane; chloroform; acetone; benzene;
DOI:10.1021/jm00362a015