3-nitro-4-((1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methylamino)benzaldehyde

Base Information

• Chemical Name: 3-nitro-4-((1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methylamino)benzaldehyde
• CAS No.: 1575819-72-5
• Molecular Formula: C₁₄H₁₄F₃N₃O₄
• Molecular Weight: 345.278

Synonyms:3-nitro-4-((1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methylamino)benzaldehyde

Chemical Property of 3-nitro-4-((1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methylamino)benzaldehyde

Chemical Property:

Purity/Quality:

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Technology Process of 3-nitro-4-((1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methylamino)benzaldehyde

There total 3 articles about 3-nitro-4-((1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methylamino)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluoro-3-nitrobenzaldehyde (42564-51-2) → 3-nitro-4-((1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methylamino)benzaldehyde (1575819-72-5)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 20 °C

2: dichloromethane / 1.5 h / 0 - 20 °C

3: pyridine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;

Reference yield:

tert-butyl 2-((4-formyl-2-nitrophenylamino)methyl)pyrrolidine-1-carboxylate (1575819-57-6) → 3-nitro-4-((1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methylamino)benzaldehyde (1575819-72-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 1.5 h / 0 - 20 °C

2: pyridine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With pyridine; In dichloromethane;

Reference yield:

tert-butyl 2-(aminomethyl)-pyrrolidine-1-carboxylate (177911-87-4) → 3-nitro-4-((1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methylamino)benzaldehyde (1575819-72-5)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 20 °C

2: dichloromethane / 1.5 h / 0 - 20 °C

3: pyridine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;

upstream raw materials:

tert-butyl 2-((4-formyl-2-nitrophenylamino)methyl)pyrrolidine-1-carboxylate

tert-butyl 2-(aminomethyl)-pyrrolidine-1-carboxylate

4-fluoro-3-nitrobenzaldehyde

Downstream raw materials:

tert-butyl (2-(4-chlorobenzamido)-1-((1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

tert-butyl (2-(4-chlorobenzamido)-1-(pyrrolidin-2-ylmethyl)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

tert-butyl (2-(4-chlorobenzamido)-1-((1-(2-cyanoacetyl)pyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

tert-butyl N-[[1-[[1-[4-(tert-butoxycarbonylamino)-2-cyano-4-methyl-pent-2-enoyl]pyrrolidin-2-yl]methyl]-2-[(4-chlorobenzoyl)amino]benzimidazol-5-yl]methyl]-N-[(1S)-1,2,2-trimethylpropyl]carbamate

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