2-(4-benzhydryl-3-oxo-morpholin-2-yl)-N-(4-carbamimidoyl-benzyl)-acetamide

Base Information

Chemical Name:2-(4-benzhydryl-3-oxo-morpholin-2-yl)-N-(4-carbamimidoyl-benzyl)-acetamide
CAS No.:441764-75-6
Molecular Formula:C₂₇H₂₈N₄O₃
Molecular Weight:456.544
Hs Code.:

2-(4-benzhydryl-3-oxo-morpholin-2-yl)-<i>N</i>-(4-carbamimidoyl-benzyl)-acetamide

Synonyms:2-(4-benzhydryl-3-oxo-morpholin-2-yl)-N-(4-carbamimidoyl-benzyl)-acetamide

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Chemical Property of 2-(4-benzhydryl-3-oxo-morpholin-2-yl)-N-(4-carbamimidoyl-benzyl)-acetamide

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Technology Process of 2-(4-benzhydryl-3-oxo-morpholin-2-yl)-N-(4-carbamimidoyl-benzyl)-acetamide

There total 7 articles about 2-(4-benzhydryl-3-oxo-morpholin-2-yl)-N-(4-carbamimidoyl-benzyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(4-{[2-((R)-4-Benzhydryl-3-oxo-morpholin-2-yl)-acetylamino]-methyl}-phenyl)-imino-methyl]-carbamic acid benzyl ester

: 441764-75-6
2-(4-benzhydryl-3-oxo-morpholin-2-yl)-N-(4-carbamimidoyl-benzyl)-acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 1h; atmospheric pressure;
DOI:10.1016/S0968-0896(02)00023-8

Reference yield:

: 441764-53-0
(R)-2-(2-oxo-ethoxy)-succinic acid dimethyl ester

: 441764-75-6
2-(4-benzhydryl-3-oxo-morpholin-2-yl)-N-(4-carbamimidoyl-benzyl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / molecular sieves 3 Angstroem; BH₃*py / methanol / 20 °C

2: LiOH / dioxane; H₂O / 0.67 h / 20 °C

3: HATU; DIPEA / dimethylformamide / 1 h / 0 °C

4: HATU; DIPEA / dimethylformamide / 0 - 20 °C

5: H₂ / 10 percent Pd/C / aq. ethanol / 1 h / 20 °C / atmospheric pressure

With lithium hydroxide; borane pyridine; 3 A molecular sieve; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00023-8

Reference yield:

: 441764-51-8
(R)-2-allyloxysuccinic acid dimethyl ester

: 441764-75-6
2-(4-benzhydryl-3-oxo-morpholin-2-yl)-N-(4-carbamimidoyl-benzyl)-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: N-methylmorpholine N-oxide monohydrate; OsO₄ / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol / 20 °C

2: 112 mg / NaIO₄ / tetrahydrofuran; H₂O / 0.5 h / 20 °C

3: 78 percent / molecular sieves 3 Angstroem; BH₃*py / methanol / 20 °C

4: LiOH / dioxane; H₂O / 0.67 h / 20 °C

5: HATU; DIPEA / dimethylformamide / 1 h / 0 °C

6: HATU; DIPEA / dimethylformamide / 0 - 20 °C

7: H₂ / 10 percent Pd/C / aq. ethanol / 1 h / 20 °C / atmospheric pressure

With lithium hydroxide; sodium periodate; osmium(VIII) oxide; borane pyridine; 3 A molecular sieve; hydrogen; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0968-0896(02)00023-8