N-{3-[5-(1-acetyl-1H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-2,5-difluoro-benzenesulfonamide

Base Information

Chemical Name:N-{3-[5-(1-acetyl-1H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-2,5-difluoro-benzenesulfonamide
CAS No.:1312939-67-5
Molecular Formula:C₂₉H₁₇F₄N₅O₄S
Molecular Weight:607.545
Hs Code.:

Synonyms:N-{3-[5-(1-acetyl-1H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-2,5-difluoro-benzenesulfonamide

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Chemical Property of N-{3-[5-(1-acetyl-1H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-2,5-difluoro-benzenesulfonamide

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Technology Process of N-{3-[5-(1-acetyl-1H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-2,5-difluoro-benzenesulfonamide

There total 7 articles about N-{3-[5-(1-acetyl-1H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-2,5-difluoro-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1312939-64-2
N-{2,4-difluoro-3-[5-(1H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-2,5-difluoro-benzenesulfonamide

: 108-24-7
acetic anhydride

: 1312939-67-5
N-{3-[5-(1-acetyl-1H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-2,5-difluoro-benzenesulfonamide

Guidance literature:: In water; ethyl acetate; at 20 ℃;

Reference yield:

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1312939-67-5
N-{3-[5-(1-acetyl-1H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-2,5-difluoro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydroxide / methanol / 20 °C / Inert atmosphere

2: Dess-Martin periodane / tetrahydrofuran / 2 h / 20 °C

3: trimethylsilyl iodide / acetonitrile / 20 °C / Inert atmosphere

4: pyridine / tetrahydrofuran / 24 h / 20 °C

5: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 0.83 h / 140 °C / microwave irradiation

6: ethyl acetate; water / 20 °C

With pyridine; trimethylsilyl iodide; potassium carbonate; Dess-Martin periodane; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; water; ethyl acetate; acetonitrile;

Reference yield:

: 1309431-01-3
methyl N-(2,4-difluoro-3-formyl-phenyl)carbamate

: 1312939-67-5
N-{3-[5-(1-acetyl-1H-indazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-2,5-difluoro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydroxide / methanol / 20 °C / Inert atmosphere

2: Dess-Martin periodane / tetrahydrofuran / 2 h / 20 °C

3: trimethylsilyl iodide / acetonitrile / 20 °C / Inert atmosphere

4: pyridine / tetrahydrofuran / 24 h / 20 °C

5: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 0.83 h / 140 °C / microwave irradiation

6: ethyl acetate; water / 20 °C

With pyridine; trimethylsilyl iodide; potassium carbonate; Dess-Martin periodane; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; water; ethyl acetate; acetonitrile;