C₃₉H₆₃NO₅Si₂

Base Information

• Chemical Name: C₃₉H₆₃NO₅Si₂
• CAS No.: 871357-02-7
• Molecular Formula: C₃₉H₆₃NO₅Si₂
• Molecular Weight: 682.104
• Mol file: 871357-02-7.mol

Synonyms:C₃₉H₆₃NO₅Si₂

Chemical Property of C₃₉H₆₃NO₅Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₃₉H₆₃NO₅Si₂

There total 8 articles about C₃₉H₆₃NO₅Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

toluene-4-sulfonic acid 3-bromo-1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-but-3-enyl ester (871355-80-5) + (4R)-4-((tert-butyldimethylsilyl)oxy)-N-methoxy-N,2-dimethyl-7-oxoheptanamide (871356-89-7) → C39H63NO5Si2 (871357-02-7)

Guidance literature:

toluene-4-sulfonic acid 3-bromo-1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-but-3-enyl ester; (4R)-4-((tert-butyldimethylsilyl)oxy)-N-methoxy-N,2-dimethyl-7-oxoheptanamide; With chromium dichloride; (R)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methanesulfonamide; triethylamine; nickel dichloride; In tetrahydrofuran; at 0 - 35 ℃;

With ethylenediamine; In tetrahydrofuran; at 0 - 25 ℃; for 0.5h;

Reference yield:

C46H71NO8SSi2 (1424343-98-5) → C39H63NO5Si2 (871357-02-7) + C39H63NO5Si2 (1139773-92-4)

Guidance literature:

With silica gel; In isopropyl alcohol; at 25 ℃;

DOI:10.1055/s-0032-1317920

Reference yield:

C7H13BrO2 (871348-26-4) → C39H63NO5Si2 (871357-02-7) + C39H63NO5Si2 (1139773-92-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 15 °C

2: Chiralpak-OD / Resolution of racemate

3: triethylamine; dmap / dichloromethane / 20 °C

4: (R)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methanesulfonamide; nickel dichloride; chromium dichloride / tetrahydrofuran / 25 °C

5: silica gel / isopropyl alcohol / 25 °C

With 1H-imidazole; chromium dichloride; dmap; (R)-N-(2-(4-isopropyl-4,5-dihydrooxazol-2-yl)-6-methylphenyl)methanesulfonamide; silica gel; triethylamine; nickel dichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; 4: |Nozaki-Hiyama-Kishi Reaction;

DOI:10.1055/s-0032-1317920

upstream raw materials:

toluene-4-sulfonic acid 3-bromo-1-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-but-3-enyl ester

(4R)-4-((tert-butyldimethylsilyl)oxy)-N-methoxy-N,2-dimethyl-7-oxoheptanamide

C₄₆H₇₁NO₈SSi₂

C₇H₁₃BrO₂

Downstream raw materials:

C₃₈H₆₀O₄Si₂