N-allyl-N-((S)-1-(2-((1S,2S)-3-(allyloxy)-1,2-dimethoxypropyl)phenylamino)-4-methyl-1-oxopentan-2-yl)cyclopropanecarboxamide

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Chemical Name:N-allyl-N-((S)-1-(2-((1S,2S)-3-(allyloxy)-1,2-dimethoxypropyl)phenylamino)-4-methyl-1-oxopentan-2-yl)cyclopropanecarboxamide
CAS No.:1421051-56-0
Molecular Formula:C₂₇H₄₀N₂O₅
Molecular Weight:472.625
Hs Code.:

Synonyms:N-allyl-N-((S)-1-(2-((1S,2S)-3-(allyloxy)-1,2-dimethoxypropyl)phenylamino)-4-methyl-1-oxopentan-2-yl)cyclopropanecarboxamide

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Chemical Property of N-allyl-N-((S)-1-(2-((1S,2S)-3-(allyloxy)-1,2-dimethoxypropyl)phenylamino)-4-methyl-1-oxopentan-2-yl)cyclopropanecarboxamide

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Technology Process of N-allyl-N-((S)-1-(2-((1S,2S)-3-(allyloxy)-1,2-dimethoxypropyl)phenylamino)-4-methyl-1-oxopentan-2-yl)cyclopropanecarboxamide

There total 5 articles about N-allyl-N-((S)-1-(2-((1S,2S)-3-(allyloxy)-1,2-dimethoxypropyl)phenylamino)-4-methyl-1-oxopentan-2-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.3%

: 1421051-48-0
(S)-2-(allylamino)-N-(2-((1S,2S)-3-(allyloxy)-1,2-dimethoxypropyl)phenyl)-4-methylpentanamide

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1421051-56-0
N-allyl-N-((S)-1-(2-((1S,2S)-3-(allyloxy)-1,2-dimethoxypropyl)phenylamino)-4-methyl-1-oxopentan-2-yl)cyclopropanecarboxamide

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 0.0833333h;
DOI:10.1021/ol3032126

Reference yield:

: C₁₄H₁₉NO₅

: 1421051-56-0
N-allyl-N-((S)-1-(2-((1S,2S)-3-(allyloxy)-1,2-dimethoxypropyl)phenylamino)-4-methyl-1-oxopentan-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; zinc / ethanol / 0.5 h / 0 - 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 3 h / 20 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.08 h / 20 °C

4: triethylamine / methanol / 12 h / Reflux

5: dichloromethane / 0.08 h / 0 - 20 °C

With acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/ol3032126

Reference yield:

: 1421051-42-4
C₂₀H₃₂N₂O₄

: 1421051-56-0
N-allyl-N-((S)-1-(2-((1S,2S)-3-(allyloxy)-1,2-dimethoxypropyl)phenylamino)-4-methyl-1-oxopentan-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / methanol / 12 h / Reflux

2: dichloromethane / 0.08 h / 0 - 20 °C

With triethylamine; In methanol; dichloromethane;
DOI:10.1021/ol3032126