(S)-3-Benzyloxy-2-[(2S,3R)-3-benzyloxy-2-((S)-2-{[(2S,3R)-3-((1S,2R)-2-hydroxy-1-methyl-pentadecyl)-oxiranecarbonyl]-amino}-3-methyl-butyrylamino)-butyrylamino]-propionic acid allyl ester

Base Information

Chemical Name:(S)-3-Benzyloxy-2-[(2S,3R)-3-benzyloxy-2-((S)-2-{[(2S,3R)-3-((1S,2R)-2-hydroxy-1-methyl-pentadecyl)-oxiranecarbonyl]-amino}-3-methyl-butyrylamino)-butyrylamino]-propionic acid allyl ester
CAS No.:867038-89-9
Molecular Formula:C₄₈H₇₃N₃O₉
Molecular Weight:836.122
Hs Code.:

(S)-3-Benzyloxy-2-[(2S,3R)-3-benzyloxy-2-((S)-2-{[(2S,3R)-3-((1S,2R)-2-hydroxy-1-methyl-pentadecyl)-oxiranecarbonyl]-amino}-3-methyl-butyrylamino)-butyrylamino]-propionic acid allyl ester

Synonyms:(S)-3-Benzyloxy-2-[(2S,3R)-3-benzyloxy-2-((S)-2-{[(2S,3R)-3-((1S,2R)-2-hydroxy-1-methyl-pentadecyl)-oxiranecarbonyl]-amino}-3-methyl-butyrylamino)-butyrylamino]-propionic acid allyl ester

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Chemical Property of (S)-3-Benzyloxy-2-[(2S,3R)-3-benzyloxy-2-((S)-2-{[(2S,3R)-3-((1S,2R)-2-hydroxy-1-methyl-pentadecyl)-oxiranecarbonyl]-amino}-3-methyl-butyrylamino)-butyrylamino]-propionic acid allyl ester

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Technology Process of (S)-3-Benzyloxy-2-[(2S,3R)-3-benzyloxy-2-((S)-2-{[(2S,3R)-3-((1S,2R)-2-hydroxy-1-methyl-pentadecyl)-oxiranecarbonyl]-amino}-3-methyl-butyrylamino)-butyrylamino]-propionic acid allyl ester

There total 15 articles about (S)-3-Benzyloxy-2-[(2S,3R)-3-benzyloxy-2-((S)-2-{[(2S,3R)-3-((1S,2R)-2-hydroxy-1-methyl-pentadecyl)-oxiranecarbonyl]-amino}-3-methyl-butyrylamino)-butyrylamino]-propionic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 452956-81-9
(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-hexadecanal

: 867038-89-9
(S)-3-Benzyloxy-2-[(2S,3R)-3-benzyloxy-2-((S)-2-{[(2S,3R)-3-((1S,2R)-2-hydroxy-1-methyl-pentadecyl)-oxiranecarbonyl]-amino}-3-methyl-butyrylamino)-butyrylamino]-propionic acid allyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / benzene / 12 h / Heating

2: 98 percent / DIBAL-H / CH₂Cl₂ / 0.5 h / -78 °C

3: 91 percent / Ti(i-PrO)4; (-)-DET; TBHP / CH₂Cl₂; decane / 24 h / -20 °C

4: 64 percent / NaIO₄; RuCl₃ / CCl₄; acetonitrile; H₂O / 0.5 h / 0 °C

5: 74 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 0.33 h / 25 °C

6: HF*pyridine / tetrahydrofuran / 12 h / 25 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; ruthenium trichloride; sodium periodate; diisobutylaluminium hydride; pyridine hydrogenfluoride; (-)-diethyl tartrate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; tetrachloromethane; decane; dichloromethane; water; acetonitrile; benzene; 3: Sharpless asymmetric epoxidation;
DOI:10.1021/jo050625l

Reference yield:

: 623936-80-1
(E)-(4R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-octadec-2-en-1-ol

: 867038-89-9
(S)-3-Benzyloxy-2-[(2S,3R)-3-benzyloxy-2-((S)-2-{[(2S,3R)-3-((1S,2R)-2-hydroxy-1-methyl-pentadecyl)-oxiranecarbonyl]-amino}-3-methyl-butyrylamino)-butyrylamino]-propionic acid allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / Ti(i-PrO)4; (-)-DET; TBHP / CH₂Cl₂; decane / 24 h / -20 °C

2: 64 percent / NaIO₄; RuCl₃ / CCl₄; acetonitrile; H₂O / 0.5 h / 0 °C

3: 74 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 0.33 h / 25 °C

4: HF*pyridine / tetrahydrofuran / 12 h / 25 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; ruthenium trichloride; sodium periodate; pyridine hydrogenfluoride; (-)-diethyl tartrate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; tetrachloromethane; decane; dichloromethane; water; acetonitrile; 1: Sharpless asymmetric epoxidation;
DOI:10.1021/jo050625l

Reference yield:

: 623936-79-8
(E)-(4R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-octadec-2-enoic acid methyl ester

: 867038-89-9
(S)-3-Benzyloxy-2-[(2S,3R)-3-benzyloxy-2-((S)-2-{[(2S,3R)-3-((1S,2R)-2-hydroxy-1-methyl-pentadecyl)-oxiranecarbonyl]-amino}-3-methyl-butyrylamino)-butyrylamino]-propionic acid allyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / DIBAL-H / CH₂Cl₂ / 0.5 h / -78 °C

2: 91 percent / Ti(i-PrO)4; (-)-DET; TBHP / CH₂Cl₂; decane / 24 h / -20 °C

3: 64 percent / NaIO₄; RuCl₃ / CCl₄; acetonitrile; H₂O / 0.5 h / 0 °C

4: 74 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 0.33 h / 25 °C

5: HF*pyridine / tetrahydrofuran / 12 h / 25 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; ruthenium trichloride; sodium periodate; diisobutylaluminium hydride; pyridine hydrogenfluoride; (-)-diethyl tartrate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; tetrachloromethane; decane; dichloromethane; water; acetonitrile; 2: Sharpless asymmetric epoxidation;
DOI:10.1021/jo050625l