diphenylmethyl 7β-(2-thienylacetylamino)-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylate

Base Information

Chemical Name:diphenylmethyl 7β-(2-thienylacetylamino)-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylate
CAS No.:53090-88-3
Molecular Formula:C₂₉H₂₆N₆O₄S₃
Molecular Weight:618.761
Hs Code.:

Synonyms:diphenylmethyl 7β-(2-thienylacetylamino)-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylate

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Chemical Property of diphenylmethyl 7β-(2-thienylacetylamino)-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylate

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Technology Process of diphenylmethyl 7β-(2-thienylacetylamino)-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylate

There total 6 articles about diphenylmethyl 7β-(2-thienylacetylamino)-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 83262-96-8,83262-97-9,139164-94-6
diphenylmethyl 7β-(2-thienylacetylamino)-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylate 1α-oxide

: 53090-88-3
diphenylmethyl 7β-(2-thienylacetylamino)-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylate

Guidance literature:: With acetyl chloride; tin(ll) chloride; In N,N-dimethyl-formamide; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(01)92145-3

Reference yield: 57.0%

: 32924-66-6
Keftet

: 908093-98-1
diazodiphenylmethane

: 53090-88-3
(6R,7R)-3-(1-Methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: In methanol; dichloromethane; for 2h; Ambient temperature;

Reference yield:

: 53994-64-2,56246-77-6
(2R,7R)-3-Methylene-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

: 53090-88-3
diphenylmethyl 7β-(2-thienylacetylamino)-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: Cl₂ / 1.) CCl₄, 20 min, 0 deg C, 2.) CH₂Cl₂, r.t., 2,5 h

2: methanol; acetone / 0.33 h / Heating

3: 70 percent / m-CPBA / CH₂Cl₂ / 0.5 h / 0 °C

4: 97 percent / SnCl₂*2H₂O, acetylchloride / dimethylformamide / 1 h / Ambient temperature

With chlorine; acetyl chloride; 3-chloro-benzenecarboperoxoic acid; tin(ll) chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)92145-3