(2S,3R,5S,6S)-2-isopropyloxy-3,5-dimethyl-6-<(1S)-2-(4-methoxybenzyl)oxy-1-methylethyl>tetrahydropyran

Base Information

Chemical Name:(2S,3R,5S,6S)-2-isopropyloxy-3,5-dimethyl-6-<(1S)-2-(4-methoxybenzyl)oxy-1-methylethyl>tetrahydropyran
CAS No.:114144-60-4
Molecular Formula:C₂₁H₃₄O₄
Molecular Weight:350.499
Hs Code.:

Synonyms:(2S,3R,5S,6S)-2-isopropyloxy-3,5-dimethyl-6-<(1S)-2-(4-methoxybenzyl)oxy-1-methylethyl>tetrahydropyran

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Chemical Property of (2S,3R,5S,6S)-2-isopropyloxy-3,5-dimethyl-6-<(1S)-2-(4-methoxybenzyl)oxy-1-methylethyl>tetrahydropyran

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Technology Process of (2S,3R,5S,6S)-2-isopropyloxy-3,5-dimethyl-6-<(1S)-2-(4-methoxybenzyl)oxy-1-methylethyl>tetrahydropyran

There total 1 articles about (2S,3R,5S,6S)-2-isopropyloxy-3,5-dimethyl-6-<(1S)-2-(4-methoxybenzyl)oxy-1-methylethyl>tetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 90093-98-4
(2S,3R,5S,6S)-2-isopropyloxy-3,5-dimethyl-6-<1(S)-methyl-2-hydroxyethyl>tetrahydropyran

: 824-94-2
p-methoxybenzyl chloride

: 114144-60-4
(2S,3R,5S,6S)-2-isopropyloxy-3,5-dimethyl-6-<(1S)-2-(4-methoxybenzyl)oxy-1-methylethyl>tetrahydropyran

Guidance literature:: With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; Ambient temperature;
DOI:10.1248/cpb.35.2196

Reference yield: 81.0%

: 114144-60-4
(2S,3R,5S,6S)-2-isopropyloxy-3,5-dimethyl-6-<(1S)-2-(4-methoxybenzyl)oxy-1-methylethyl>tetrahydropyran

: (3R,5S,6S)-6-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3,5-dimethyl-tetrahydro-pyran-2-ol

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 50 ℃; for 5h;
DOI:10.1248/cpb.35.2196

Reference yield:

: 114144-60-4
(2S,3R,5S,6S)-2-isopropyloxy-3,5-dimethyl-6-<(1S)-2-(4-methoxybenzyl)oxy-1-methylethyl>tetrahydropyran

: 114144-63-7
(2R,4S,5S,6S)-5-tert-butyldimethylsilyloxy-7-(4-methoxybenzyl)oxy-2,4,6-trimethylheptanol

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / 1 N HCl / tetrahydrofuran / 5 h / 50 °C

2: 95 percent / NaBH₄, CaCl₂ / ethanol / 3 h / Ambient temperature

3: 94 percent / imidazole / dimethylformamide / 30 h / 90 °C

4: 77 percent / Bu₄NF / tetrahydrofuran / 10 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; tetrabutyl ammonium fluoride; calcium chloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.2196