2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]oxyacetic acid

Base Information

Chemical Name:2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]oxyacetic acid
CAS No.:1353487-23-6
Molecular Formula:C₂₇H₂₁ClN₂O₅
Molecular Weight:488.927
Hs Code.:

Synonyms:2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]oxyacetic acid

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Chemical Property of 2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]oxyacetic acid

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Technology Process of 2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]oxyacetic acid

There total 10 articles about 2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]oxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1374249-71-4
tert-butyl 1-(4-{2-[(4-chlorophenyl)ethylamino]carbonyl}phenylcarbonyl)isoquinolin-4-yloxyacetate

: 1353487-23-6
2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]oxyacetic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

: 66728-98-1
4-bromo-1-chloroisoqionoline

: 1353487-23-6
2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]oxyacetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 80 °C

3: ; sodium hydrogencarbonate / water; acetone / 0 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5: water; sodium hydroxide / tetrahydrofuran / 20 °C

6: water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 20 °C

7: sodium hydroxide / tetrahydrofuran / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; sodium hexamethyldisilazane; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; chloroform; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

: 1374249-67-8
1-{4-(methoxycarbonyl)phenylcarbonyl}-4-(3,3,5,5,-tetramethyl-2,5-dioxaborolidin-1-y1)isoquinoline

: 1353487-23-6
2-[1-[4-[2-(4-chlorophenyl)ethylcarbamoyl]benzoyl]isoquinolin-4-yl]oxyacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: ; sodium hydrogencarbonate / water; acetone / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: water; sodium hydroxide / tetrahydrofuran / 20 °C

4: water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 20 °C

5: sodium hydroxide / tetrahydrofuran / 20 °C

With water; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; chloroform; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2012.03.009