N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-ethyl}-oxalamic acid tert-butyl ester

Base Information

Chemical Name:N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-ethyl}-oxalamic acid tert-butyl ester
CAS No.:220193-81-7
Molecular Formula:C₄₈H₆₈N₅O₁₀P
Molecular Weight:906.069
Hs Code.:

<i>N</i>-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(di-<i>tert</i>-butoxy-phosphorylmethyl)-phenyl]-ethyl}-oxalamic acid <i>tert</i>-butyl ester

Synonyms:N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-ethyl}-oxalamic acid tert-butyl ester

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Chemical Property of N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-ethyl}-oxalamic acid tert-butyl ester

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Technology Process of N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-ethyl}-oxalamic acid tert-butyl ester

There total 5 articles about N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-ethyl}-oxalamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 39061-59-1
t-butoxalyl chloride

: 220193-83-9
[4-((S)-2-Amino-2-{1-[(S)-2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-benzyl]-phosphonic acid di-tert-butyl ester

: 220193-81-7
N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-ethyl}-oxalamic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
DOI:10.1080/00304940009356287

Reference yield:

: {4-[2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester

: 220193-81-7
N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-ethyl}-oxalamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / acetonitrile / 1 h / 20 °C

2: 87 percent / diisopropylethylamine / dimethylformamide / 0.5 h / 20 °C

With piperidine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile; 1: Substitution / 2: Acylation;
DOI:10.1080/00304940009356287

Reference yield:

: 220193-52-2
(2S)-2-amino-N₁-[3-(1-naphthalenyl)propyl]butanediamide

: 220193-81-7
N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-ethyl}-oxalamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) DIPCDI, HOBT*H₂O / 1.) DMF, RT, 10 min, 2.) DMF, RT, overnight

2: 1.) piperidine, 2.) DIEA / 1.) CH₃CN, RT, 2 h, 2.) DMF, 10 min

With piperidine; 1,3-di-tert-butylcarbodiimide; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine;
DOI:10.1021/jm980388x