1-(4-(hydroxy(1-methyl-1H-imidazol-5-yl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone

Base Information

Chemical Name:1-(4-(hydroxy(1-methyl-1H-imidazol-5-yl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone
CAS No.:1600566-75-3
Molecular Formula:C₂₉H₂₆F₆N₄O₂
Molecular Weight:576.541
Hs Code.:

Synonyms:1-(4-(hydroxy(1-methyl-1H-imidazol-5-yl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone

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Chemical Property of 1-(4-(hydroxy(1-methyl-1H-imidazol-5-yl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone

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Technology Process of 1-(4-(hydroxy(1-methyl-1H-imidazol-5-yl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone

There total 9 articles about 1-(4-(hydroxy(1-methyl-1H-imidazol-5-yl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1600562-93-3
6-iodo-3-phenyl-2,4-bis(trifluoromethyl)quinoline

: 1599529-40-4
1-(4-(1-methyl-1H-imidazole-5-carbonyl)piperidin-1-yl)ethanone

: 1600566-75-3
1-(4-(hydroxy(1-methyl-1H-imidazol-5-yl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone

Guidance literature:: 6-iodo-3-phenyl-2,4-bis(trifluoromethyl)quinoline; With isopropylmagnesium chloride; In tetrahydrofuran; for 0.333333h; Inert atmosphere;

1-(4-(1-methyl-1H-imidazole-5-carbonyl)piperidin-1-yl)ethanone; In tetrahydrofuran; for 2.41667h; Inert atmosphere;

With water-d2; In tetrahydrofuran; Inert atmosphere;

Reference yield:

: 137076-22-3
tert butyl 4-formylpiperidine-1-carboxylate

: 1600566-75-3
1-(4-(hydroxy(1-methyl-1H-imidazol-5-yl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropylmagnesium chloride / dichloromethane; tetrahydrofuran / 0.42 h / Cooling with ice; Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: manganese(IV) oxide / 1,4-dioxane / 455.28 h / 20 - 100 °C

3.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

4.1: triethylamine / dichloromethane; toluene / 1 h / 20 °C

5.1: isopropylmagnesium chloride / tetrahydrofuran / 0.33 h / Ca.-70 -20 °C / Inert atmosphere

5.2: 2.42 h / Inert atmosphere

5.3: Inert atmosphere

With manganese(IV) oxide; isopropylmagnesium chloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 1599529-39-1
tert-butyl 4-(hydroxy(1-methyl-1H-imidazol-5-yl)methyl)piperidine-1-carboxylate

: 1600566-75-3
1-(4-(hydroxy(1-methyl-1H-imidazol-5-yl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: manganese(IV) oxide / 1,4-dioxane / 455.28 h / 20 - 100 °C

2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

3.1: triethylamine / dichloromethane; toluene / 1 h / 20 °C

4.1: isopropylmagnesium chloride / tetrahydrofuran / 0.33 h / Ca.-70 -20 °C / Inert atmosphere

4.2: 2.42 h / Inert atmosphere

4.3: Inert atmosphere

With manganese(IV) oxide; isopropylmagnesium chloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;