(1R,2R)-2-N-(tetradecanoylamino)-1-(4'-nitrophenyl)-3-hydroxypropyl-1-O-(N,N-dimethylamino)acetate

Base Information

Chemical Name:(1R,2R)-2-N-(tetradecanoylamino)-1-(4'-nitrophenyl)-3-hydroxypropyl-1-O-(N,N-dimethylamino)acetate
CAS No.:1226851-12-2
Molecular Formula:C₂₇H₄₅N₃O₆
Molecular Weight:507.671
Hs Code.:

Synonyms:(1R,2R)-2-N-(tetradecanoylamino)-1-(4'-nitrophenyl)-3-hydroxypropyl-1-O-(N,N-dimethylamino)acetate

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Chemical Property of (1R,2R)-2-N-(tetradecanoylamino)-1-(4'-nitrophenyl)-3-hydroxypropyl-1-O-(N,N-dimethylamino)acetate

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Technology Process of (1R,2R)-2-N-(tetradecanoylamino)-1-(4'-nitrophenyl)-3-hydroxypropyl-1-O-(N,N-dimethylamino)acetate

There total 3 articles about (1R,2R)-2-N-(tetradecanoylamino)-1-(4'-nitrophenyl)-3-hydroxypropyl-1-O-(N,N-dimethylamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: (1R,2R)-2-N-(tetradecanoylamino)-1-(4'-nitrophenyl)-3-O-tritylpropyl-1-O-(N,N-dimethylamino)acetate

: 1226851-12-2
(1R,2R)-2-N-(tetradecanoylamino)-1-(4'-nitrophenyl)-3-hydroxypropyl-1-O-(N,N-dimethylamino)acetate

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 4 - 20 ℃; for 1h;
DOI:10.1016/j.bmc.2014.10.025

Reference yield:

: 35922-06-6
(1R,2R)-2-N-(tetradecanoylamino)-1-(4'-nitrophenyl)-1,3-propandiol

: 1226851-12-2
(1R,2R)-2-N-(tetradecanoylamino)-1-(4'-nitrophenyl)-3-hydroxypropyl-1-O-(N,N-dimethylamino)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / dichloromethane / 20 °C

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 20 °C

2.2: 20 °C

3.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 4 - 20 °C

With dmap; boron trifluoride diethyl etherate; 1,1'-carbonyldiimidazole; In dichloromethane;
DOI:10.1016/j.bmc.2014.10.025

Reference yield:

: N-((1R,2R)-1-hydroxy-1-(4-nitrophenyl)-3-(trityloxy)propan-2-yl)tetra-decanamide

: 1226851-12-2
(1R,2R)-2-N-(tetradecanoylamino)-1-(4'-nitrophenyl)-3-hydroxypropyl-1-O-(N,N-dimethylamino)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 20 °C

1.2: 20 °C

2.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 4 - 20 °C

With boron trifluoride diethyl etherate; 1,1'-carbonyldiimidazole; In dichloromethane;
DOI:10.1016/j.bmc.2014.10.025