2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-(4-fluorophenyl)piperidin-4-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

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Chemical Name:2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-(4-fluorophenyl)piperidin-4-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol
CAS No.:1443427-33-5
Molecular Formula:C₂₈H₂₃F₅N₆O
Molecular Weight:554.522
Hs Code.:

Synonyms:2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-(4-fluorophenyl)piperidin-4-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

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Chemical Property of 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-(4-fluorophenyl)piperidin-4-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

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Technology Process of 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-(4-fluorophenyl)piperidin-4-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

There total 7 articles about 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-(4-fluorophenyl)piperidin-4-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288-94-8
1H-tetrazole

: 1443429-57-9
C₂₇H₂₁F₅N₂O

: 1443427-33-5
2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-(4-fluorophenyl)piperidin-4-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 16h; Temperature; Inert atmosphere;

Reference yield:

: 1416860-92-8
6-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridin-3-ol

: 1443427-33-5
2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-(4-fluorophenyl)piperidin-4-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.33 h / 0 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 65 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1443427-33-5
2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-((1-(4-fluorophenyl)piperidin-4-yl)ethynyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper diacetate; pyridine / dichloromethane / 16 h / 20 °C / Molecular sieve

2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / -78 °C / Inert atmosphere

2.2: -78 - 20 °C

3.1: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere

4.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 65 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; oxalyl dichloride; copper diacetate; potassium carbonate; dimethyl sulfoxide; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;