ethyl N-(tert-butyloxycarbonyl)-3-<(carbobenzoxy)methyl>-DL-phenylalaninate

Base Information

Chemical Name:ethyl N-(tert-butyloxycarbonyl)-3-<(carbobenzoxy)methyl>-DL-phenylalaninate
CAS No.:141879-59-6
Molecular Formula:C₂₅H₃₁NO₆
Molecular Weight:441.524
Hs Code.:

Synonyms:ethyl N-(tert-butyloxycarbonyl)-3-<(carbobenzoxy)methyl>-DL-phenylalaninate

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Chemical Property of ethyl N-(tert-butyloxycarbonyl)-3-<(carbobenzoxy)methyl>-DL-phenylalaninate

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Technology Process of ethyl N-(tert-butyloxycarbonyl)-3-<(carbobenzoxy)methyl>-DL-phenylalaninate

There total 3 articles about ethyl N-(tert-butyloxycarbonyl)-3-<(carbobenzoxy)methyl>-DL-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 141879-58-5
ethyl 3-<(carbobenzoxy)methyl>-DL-phenylalaninate

: 141879-59-6
ethyl N-(tert-butyloxycarbonyl)-3-<(carbobenzoxy)methyl>-DL-phenylalaninate

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; for 3h;
DOI:10.1021/jm00092a005

Reference yield:

: 141879-55-2
benzyl 3-(bromomethyl)phenylacetate

: 141879-59-6
ethyl N-(tert-butyloxycarbonyl)-3-<(carbobenzoxy)methyl>-DL-phenylalaninate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / KI, 40percent aq. benzyltrimethylammonium hydroxide / dioxane / 3 h / Ambient temperature

2: 40 percent / 1 M aq. HCl / diethyl ether / 2 h / Ambient temperature

3: 46 percent / tetrahydrofuran / 3 h / 0 - 20 °C

With hydrogenchloride; N-benzyl-trimethylammonium hydroxide; potassium iodide; In tetrahydrofuran; 1,4-dioxane; diethyl ether;
DOI:10.1021/jm00092a005

Reference yield:

: 141879-57-4
ethyl N-(diphenylmethylene)-3-<(carbobenzoxy)methyl>-DL-phenylalaninate

: 141879-59-6
ethyl N-(tert-butyloxycarbonyl)-3-<(carbobenzoxy)methyl>-DL-phenylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / 1 M aq. HCl / diethyl ether / 2 h / Ambient temperature

2: 46 percent / tetrahydrofuran / 3 h / 0 - 20 °C

With hydrogenchloride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jm00092a005