Phosphoric acid (R)-3-(4-benzyloxy-phenyl)-2-((Z)-octadec-9-enoylamino)-3-oxo-propyl ester di-tert-butyl ester

Base Information

Chemical Name:Phosphoric acid (R)-3-(4-benzyloxy-phenyl)-2-((Z)-octadec-9-enoylamino)-3-oxo-propyl ester di-tert-butyl ester
CAS No.:870862-72-9
Molecular Formula:C₄₂H₆₆NO₇P
Molecular Weight:727.962
Hs Code.:

Synonyms:Phosphoric acid (R)-3-(4-benzyloxy-phenyl)-2-((Z)-octadec-9-enoylamino)-3-oxo-propyl ester di-tert-butyl ester

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Chemical Property of Phosphoric acid (R)-3-(4-benzyloxy-phenyl)-2-((Z)-octadec-9-enoylamino)-3-oxo-propyl ester di-tert-butyl ester

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Technology Process of Phosphoric acid (R)-3-(4-benzyloxy-phenyl)-2-((Z)-octadec-9-enoylamino)-3-oxo-propyl ester di-tert-butyl ester

There total 4 articles about Phosphoric acid (R)-3-(4-benzyloxy-phenyl)-2-((Z)-octadec-9-enoylamino)-3-oxo-propyl ester di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 137348-86-8
di-tert-butyl diisopropylphosphoramide

: 870862-71-8
(Z)-Octadec-9-enoic acid [(R)-2-(4-benzyloxy-phenyl)-1-hydroxymethyl-2-oxo-ethyl]-amide

: 870862-72-9
Phosphoric acid (R)-3-(4-benzyloxy-phenyl)-2-((Z)-octadec-9-enoylamino)-3-oxo-propyl ester di-tert-butyl ester

Guidance literature:: di-tert-butyl diisopropylphosphoramide; (Z)-Octadec-9-enoic acid [(R)-2-(4-benzyloxy-phenyl)-1-hydroxymethyl-2-oxo-ethyl]-amide; With 1H-tetrazole; for 4h;

With dihydrogen peroxide; for 4h;
DOI:10.1016/j.bmcl.2004.03.076

Reference yield:

: 112-77-6
(Z)-9-octadecenoyl chloride

: 870862-72-9
Phosphoric acid (R)-3-(4-benzyloxy-phenyl)-2-((Z)-octadec-9-enoylamino)-3-oxo-propyl ester di-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 77 percent / DIEA / CH₂Cl₂ / 4 h

2.1: tetrazole / 4 h

2.2: 75 percent / aq. H₂O₂ / 4 h

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2004.03.076

Reference yield:

: 488835-95-6
(4R)-4-(4-benzyloxyphenyl)-3-tert-butoxycarbonyl-2,2-dimethyloxazolidine

: 870862-72-9
Phosphoric acid (R)-3-(4-benzyloxy-phenyl)-2-((Z)-octadec-9-enoylamino)-3-oxo-propyl ester di-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h

3.1: 1H-tetrazole / 4 h

3.2: 4 h

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane;