1,1,1-trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(6-methyl-1-[3-(methyloxy)phenyl]-1H-indazol-4-yl)amino]methyl}-2-pentanol

Base Information

Chemical Name:1,1,1-trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(6-methyl-1-[3-(methyloxy)phenyl]-1H-indazol-4-yl)amino]methyl}-2-pentanol
CAS No.:913003-58-4
Molecular Formula:C₂₉H₃₁F₄N₃O₃
Molecular Weight:545.577
Hs Code.:

Synonyms:1,1,1-trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(6-methyl-1-[3-(methyloxy)phenyl]-1H-indazol-4-yl)amino]methyl}-2-pentanol

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Chemical Property of 1,1,1-trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(6-methyl-1-[3-(methyloxy)phenyl]-1H-indazol-4-yl)amino]methyl}-2-pentanol

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Technology Process of 1,1,1-trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(6-methyl-1-[3-(methyloxy)phenyl]-1H-indazol-4-yl)amino]methyl}-2-pentanol

There total 6 articles about 1,1,1-trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(6-methyl-1-[3-(methyloxy)phenyl]-1H-indazol-4-yl)amino]methyl}-2-pentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913003-01-7
4-bromo-6-methyl-1-[(3-methoxy)phenyl]-1H-indazole

: 611230-88-7
racemic 2-(aminomethyl)-1,1,1-trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-pentanol

: 913003-58-4
1,1,1-trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(6-methyl-1-[3-(methyloxy)phenyl]-1H-indazol-4-yl)amino]methyl}-2-pentanol

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; for 2h; Product distribution / selectivity; Heating / reflux;

Reference yield:

: 913003-02-8
1,1,1-trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(phenylmethyl)amino]methyl}-2-pentanol

: 913003-58-4
1,1,1-trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(6-methyl-1-[3-(methyloxy)phenyl]-1H-indazol-4-yl)amino]methyl}-2-pentanol

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

2: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 2 h / Heating / reflux

With hydrogen; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ethanol; toluene;

Reference yield:

: C₁₅H₁₄Br₂N₂O

: 913003-58-4
1,1,1-trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(6-methyl-1-[3-(methyloxy)phenyl]-1H-indazol-4-yl)amino]methyl}-2-pentanol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 41 h / Heating / reflux

2: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 2 h / Heating / reflux

With potassium phosphate; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene;