10-Methyl-2-(4'-chlorophenyl)-5,6-dihydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

Base Information

• Chemical Name: 10-Methyl-2-(4'-chlorophenyl)-5,6-dihydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one
• CAS No.: 118288-53-2
• Molecular Formula: C₁₉H₁₅ClN₂OS
• Molecular Weight: 354.86

Synonyms:10-Methyl-2-(4'-chlorophenyl)-5,6-dihydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

Chemical Property of 10-Methyl-2-(4'-chlorophenyl)-5,6-dihydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

Chemical Property:

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Technology Process of 10-Methyl-2-(4'-chlorophenyl)-5,6-dihydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

There total 7 articles about 10-Methyl-2-(4'-chlorophenyl)-5,6-dihydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

10-Methyl-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one (118288-49-6) → 10-Methyl-2-(4'-chlorophenyl)-5,6-dihydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one (118288-53-2)

Guidance literature:

With bromine; acetic acid; at 40 - 45 ℃; for 1h;

DOI:10.1248/cpb.39.2556

Reference yield:

7-methyl-2,3,4,5-tetrahydrobenzothiepin-5-one (18850-47-0) → 10-Methyl-2-(4'-chlorophenyl)-5,6-dihydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one (118288-53-2)

Guidance literature:

Multi-step reaction with 6 steps

2: acetone / 3 h / Ambient temperature

3: methanol; H₂O / 1 h / Ambient temperature

4: conc. HCl, AcOH / 3 h / Heating

5: 40 percent / NaOAc / ethanol / Heating

6: 67 percent / Br₂, AcOH / 1 h / 40 - 45 °C

With hydrogenchloride; bromine; sodium acetate; acetic acid; In methanol; ethanol; water; acetone;

DOI:10.1248/cpb.39.2556

Reference yield:

4-dimethylaminomethyl-7-methyl-3,4-dihydro-2H-benzo[b]thiepin-5-one (801213-99-0) → 10-Methyl-2-(4'-chlorophenyl)-5,6-dihydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one (118288-53-2)

Guidance literature:

Multi-step reaction with 5 steps

1: acetone / 3 h / Ambient temperature

2: methanol; H₂O / 1 h / Ambient temperature

3: conc. HCl, AcOH / 3 h / Heating

4: 40 percent / NaOAc / ethanol / Heating

5: 67 percent / Br₂, AcOH / 1 h / 40 - 45 °C

With hydrogenchloride; bromine; sodium acetate; acetic acid; In methanol; ethanol; water; acetone;

DOI:10.1248/cpb.39.2556

upstream raw materials:

10-Methyl-2-(4'-chlorophenyl)-4,4a,5,6-tetrahydro-(1)benzothiepino<5,4-c>pyridazin-3(2H)-one

7-methyl-2,3,4,5-tetrahydrobenzothiepin-5-one

4-dimethylaminomethyl-7-methyl-3,4-dihydro-2H-benzo[b]thiepin-5-one

7-Methyl-5-oxo-2,3,4,5-tetrahydro-1-benzothiepin-4-acetic acid

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