(S)-N-tert-butyl-4-(4-methoxyphenyl)-4-(naphthalen-2-yl)-2-oxobutanamide

Base Information

Chemical Name:(S)-N-tert-butyl-4-(4-methoxyphenyl)-4-(naphthalen-2-yl)-2-oxobutanamide
CAS No.:1637758-59-8
Molecular Formula:C₂₅H₂₇NO₃
Molecular Weight:389.494
Hs Code.:

Synonyms:(S)-N-tert-butyl-4-(4-methoxyphenyl)-4-(naphthalen-2-yl)-2-oxobutanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-tert-butyl-4-(4-methoxyphenyl)-4-(naphthalen-2-yl)-2-oxobutanamide

Chemical Property:

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Technology Process of (S)-N-tert-butyl-4-(4-methoxyphenyl)-4-(naphthalen-2-yl)-2-oxobutanamide

There total 4 articles about (S)-N-tert-butyl-4-(4-methoxyphenyl)-4-(naphthalen-2-yl)-2-oxobutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1320256-54-9
(E)-N-(tert-butyl)-4-(4-methoxyphenyl)-2-oxobut-3-enamide

: 32316-92-0
naphthalene-2-boronic acid

: 1637758-59-8
(S)-N-tert-butyl-4-(4-methoxyphenyl)-4-(naphthalen-2-yl)-2-oxobutanamide

Guidance literature:: With chlorobis(ethylene)rhodium(I) dimer; (2,6-bis((R)-tert-butylsulfinyl)phenyl)diphenylphosphine; potassium hydroxide; In dichloromethane; water; at 20 ℃; for 12h; enantioselective reaction; Glovebox; Schlenk technique;
DOI:10.1002/anie.201403325

Reference yield:

: (E)-N-(tert-butyl)-2-hydroxy-4-(4-methoxyphenyl)but-3-enamide

: 1637758-59-8
(S)-N-tert-butyl-4-(4-methoxyphenyl)-4-(naphthalen-2-yl)-2-oxobutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 20 °C

2: chlorobis(ethylene)rhodium(I) dimer; potassium hydroxide; (2,6-bis((R)-tert-butylsulfinyl)phenyl)diphenylphosphine / dichloromethane; water / 12 h / 20 °C / Glovebox; Schlenk technique

With chlorobis(ethylene)rhodium(I) dimer; (2,6-bis((R)-tert-butylsulfinyl)phenyl)diphenylphosphine; Dess-Martin periodane; potassium hydroxide; In dichloromethane; water;
DOI:10.1002/anie.201403325

Reference yield:

: 24680-50-0,71277-11-7,1963-36-6
4-methoxy-trans-cinnamaldehyde

: 1637758-59-8
(S)-N-tert-butyl-4-(4-methoxyphenyl)-4-(naphthalen-2-yl)-2-oxobutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: tin(IV) chloride; pyridine N-oxide / dichloromethane / 4 h / -78 °C

2: Dess-Martin periodane / dichloromethane / 20 °C

3: chlorobis(ethylene)rhodium(I) dimer; potassium hydroxide; (2,6-bis((R)-tert-butylsulfinyl)phenyl)diphenylphosphine / dichloromethane; water / 12 h / 20 °C / Glovebox; Schlenk technique

With pyridine N-oxide; chlorobis(ethylene)rhodium(I) dimer; (2,6-bis((R)-tert-butylsulfinyl)phenyl)diphenylphosphine; tin(IV) chloride; Dess-Martin periodane; potassium hydroxide; In dichloromethane; water;
DOI:10.1002/anie.201403325