4-(2-aminoethyl)-2,6-difluorophenol hydrochloride

Base Information

Chemical Name:4-(2-aminoethyl)-2,6-difluorophenol hydrochloride
CAS No.:59043-65-1
Molecular Formula:C₈H₉F₂NO*ClH
Molecular Weight:209.623
Hs Code.:

Synonyms:4-(2-aminoethyl)-2,6-difluorophenol hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-aminoethyl)-2,6-difluorophenol hydrochloride

Chemical Property:

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Technology Process of 4-(2-aminoethyl)-2,6-difluorophenol hydrochloride

There total 3 articles about 4-(2-aminoethyl)-2,6-difluorophenol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,6-difluoro-4-[(E)-2-nitrovinyl]phenol

: 59043-65-1
4-(2-aminoethyl)-2,6-difluorophenol hydrochloride

Guidance literature:: With hydrogenchloride; palladium 10% on activated carbon; hydrogen; at 0 - 25 ℃; for 12h; under 775.743 Torr;

Reference yield:

: 676498-83-2
C₈H₅F₂NO₃

: 59043-65-1
4-(2-aminoethyl)-2,6-difluorophenol hydrochloride

Guidance literature:: C₈H₅F₂NO₃; With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

With hydrogenchloride; In toluene; butan-1-ol;
DOI:10.1016/j.bmc.2013.11.003

Reference yield:

: 118276-06-5
3,5-difluoro-4-hydroxybenzaldehyde

: 59043-65-1
4-(2-aminoethyl)-2,6-difluorophenol hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; ammonium acetate / 2 h / Reflux

2: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 16 h / 0 - 20 °C

With aluminum (III) chloride; lithium aluminium tetrahydride; ammonium acetate; acetic acid; In tetrahydrofuran; 1: |Henry Nitro Aldol Condensation;
DOI:10.1016/j.bmc.2013.11.003