N-(tert-butyloxycarbonyl)-N-methyl-L-alanyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanine benzyl ester

Base Information

Chemical Name:N-(tert-butyloxycarbonyl)-N-methyl-L-alanyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanine benzyl ester
CAS No.:151371-01-6
Molecular Formula:C₃₈H₆₃N₅O₈
Molecular Weight:717.947
Hs Code.:

Synonyms:N-(tert-butyloxycarbonyl)-N-methyl-L-alanyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanine benzyl ester

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Chemical Property of N-(tert-butyloxycarbonyl)-N-methyl-L-alanyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanine benzyl ester

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Technology Process of N-(tert-butyloxycarbonyl)-N-methyl-L-alanyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanine benzyl ester

There total 1 articles about N-(tert-butyloxycarbonyl)-N-methyl-L-alanyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16948-16-6
N-(tert-butoxycarbonyl)-N-methyl-L-alanine

: 81135-28-6
N-methylleucylvalyl-N-methylleucylalanine benzyl ester

: 151371-01-6
N-(tert-butyloxycarbonyl)-N-methyl-L-alanyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanine benzyl ester

Guidance literature:: With 4-methyl-morpholine; pivaloyl chloride; Yield given. Multistep reaction; 1) CHCl₃, -20 deg C, 3 h, 2) CHCl₃, -20 deg C, 24 h;
DOI:10.1002/hlca.19930760415

Reference yield: 77.1%

: 151371-01-6
N-(tert-butyloxycarbonyl)-N-methyl-L-alanyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanine benzyl ester

: 151371-02-7
N-methyl-L-alanyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanine benzyl ester

Guidance literature:: With trifluoroacetic acid; at -20 ℃; for 20h;
DOI:10.1002/hlca.19930760415

Reference yield:

: 151371-01-6
N-(tert-butyloxycarbonyl)-N-methyl-L-alanyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanine benzyl ester

: N,O-isopropylidene-<(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoyl>-L-2-aminobutyryl-N-methyl-L-alanyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanine benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 77.1 percent / CF₃COOH / 20 h / -20 °C

2: 1) pivaloyl chloride, MeMorph / 1) CHCl₃, -15 deg C, 3 h, 2) CHCl₃, -15 deg C, 20 h

3: 68 percent / CF₃COOH / 18 h / -20 °C

4: 89 percent / BtOH, DCCI, MeMorph / tetrahydrofuran / 72 h / 20 °C

With 4-methyl-morpholine; pivaloyl chloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1002/hlca.19930760415