(Z)-7-((1R,2R,3R,5S)-3-Hydroxy-6-oxa-bicyclo[3.1.0]hex-2-yl)-hept-5-enoic acid methyl ester

Base Information

Chemical Name:(Z)-7-((1R,2R,3R,5S)-3-Hydroxy-6-oxa-bicyclo[3.1.0]hex-2-yl)-hept-5-enoic acid methyl ester
CAS No.:98574-69-7
Molecular Formula:C₁₃H₂₀O₄
Molecular Weight:240.299
Hs Code.:

Synonyms:(Z)-7-((1R,2R,3R,5S)-3-Hydroxy-6-oxa-bicyclo[3.1.0]hex-2-yl)-hept-5-enoic acid methyl ester

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Chemical Property of (Z)-7-((1R,2R,3R,5S)-3-Hydroxy-6-oxa-bicyclo[3.1.0]hex-2-yl)-hept-5-enoic acid methyl ester

Chemical Property:

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Technology Process of (Z)-7-((1R,2R,3R,5S)-3-Hydroxy-6-oxa-bicyclo[3.1.0]hex-2-yl)-hept-5-enoic acid methyl ester

There total 1 articles about (Z)-7-((1R,2R,3R,5S)-3-Hydroxy-6-oxa-bicyclo[3.1.0]hex-2-yl)-hept-5-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34638-25-0,38110-77-9,43119-28-4,54483-22-6,26054-46-6
(1R,5S)-2-oxabicyclo[3.3.0]oct-6-en-3-one

: 98574-69-7
(Z)-7-((1R,2R,3R,5S)-3-Hydroxy-6-oxa-bicyclo[3.1.0]hex-2-yl)-hept-5-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / peroxyacetic acid, NaOAc / acetic acid / 12 h / 23 °C

2: DIBAH / toluene / 1 h / -78 °C

3: 1) Wittig coupling

With peracetic acid; sodium acetate; diisobutylaluminium hydride; In acetic acid; toluene;
DOI:10.1016/S0040-4039(00)97481-1

Reference yield: 99.0%

: 4083-64-1
Tosyl isocyanate

: 98574-69-7
(Z)-7-((1R,2R,3R,5S)-3-Hydroxy-6-oxa-bicyclo[3.1.0]hex-2-yl)-hept-5-enoic acid methyl ester

: 130520-28-4
C₂₁H₂₇NO₇S

Guidance literature:: In toluene; at 23 ℃;
DOI:10.1016/S0040-4039(00)97481-1

Reference yield:

: 98574-69-7
(Z)-7-((1R,2R,3R,5S)-3-Hydroxy-6-oxa-bicyclo[3.1.0]hex-2-yl)-hept-5-enoic acid methyl ester

: 130520-29-5
C₂₀H₂₅NO₇S

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / toluene / 23 °C

2: 96 percent / LiOH / tetrahydrofuran; methanol; H₂O / 5 h / 23 °C

With lithium hydroxide; In tetrahydrofuran; methanol; water; toluene;
DOI:10.1016/S0040-4039(00)97481-1