2-chloro-N-((R)-1-cyclopropylethyl)-7-(4-fluorophenyl)-5,7-dihydrofuro[3,4-d]pyrimidin-4-amine

Base Information

Chemical Name:2-chloro-N-((R)-1-cyclopropylethyl)-7-(4-fluorophenyl)-5,7-dihydrofuro[3,4-d]pyrimidin-4-amine
CAS No.:1263869-09-5
Molecular Formula:C₁₇H₁₇ClFN₃O
Molecular Weight:333.793
Hs Code.:

Synonyms:2-chloro-N-((R)-1-cyclopropylethyl)-7-(4-fluorophenyl)-5,7-dihydrofuro[3,4-d]pyrimidin-4-amine

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Chemical Property of 2-chloro-N-((R)-1-cyclopropylethyl)-7-(4-fluorophenyl)-5,7-dihydrofuro[3,4-d]pyrimidin-4-amine

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Technology Process of 2-chloro-N-((R)-1-cyclopropylethyl)-7-(4-fluorophenyl)-5,7-dihydrofuro[3,4-d]pyrimidin-4-amine

There total 6 articles about 2-chloro-N-((R)-1-cyclopropylethyl)-7-(4-fluorophenyl)-5,7-dihydrofuro[3,4-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 195252-68-7
(R)-1-cyclopropylethanamine hydrochloride salt

: 1263869-01-7
2,4-dichloro-7-(4-fluorophenyl)-5,7-dihydrofuro[3,4-d]pyrimidine

: 1263869-09-5
2-chloro-N-((R)-1-cyclopropylethyl)-7-(4-fluorophenyl)-5,7-dihydrofuro[3,4-d]pyrimidin-4-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 - 40 ℃;

Reference yield:

: 50270-27-4
2,4,6-trichloropyrimidine-5-carbaldehyde

: 1263869-09-5
2-chloro-N-((R)-1-cyclopropylethyl)-7-(4-fluorophenyl)-5,7-dihydrofuro[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / benzene; water / 20 h / Reflux

2.1: diethyl ether; tetrahydrofuran / 4 h / 0 - 20 °C

2.2: Cooling with ice

3.1: hydrogenchloride; water / tetrahydrofuran / 20 °C

4.1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

5.1: caesium carbonate; lead(IV) tetraacetate / benzene / 18 h / Reflux

6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 - 40 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; water; lead(IV) tetraacetate; caesium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; water; benzene;

Reference yield:

: C₁₂H₇Cl₂FN₂O*(x)ClH

: 1263869-09-5
2-chloro-N-((R)-1-cyclopropylethyl)-7-(4-fluorophenyl)-5,7-dihydrofuro[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

2: caesium carbonate; lead(IV) tetraacetate / benzene / 18 h / Reflux

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 - 40 °C

With methanol; sodium tetrahydroborate; lead(IV) tetraacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; benzene;