ethyl (+/-)-2-oxo-2-(4-phenoxyphenyl)-1,3,2-oxazaphosphorinane-3-acetate

Base Information

• Chemical Name: ethyl (+/-)-2-oxo-2-(4-phenoxyphenyl)-1,3,2-oxazaphosphorinane-3-acetate
• CAS No.: 391640-63-4
• Molecular Formula: C₁₉H₂₂NO₅P
• Molecular Weight: 375.361

Synonyms:ethyl (+/-)-2-oxo-2-(4-phenoxyphenyl)-1,3,2-oxazaphosphorinane-3-acetate

Chemical Property of ethyl (+/-)-2-oxo-2-(4-phenoxyphenyl)-1,3,2-oxazaphosphorinane-3-acetate

Chemical Property:

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Technology Process of ethyl (+/-)-2-oxo-2-(4-phenoxyphenyl)-1,3,2-oxazaphosphorinane-3-acetate

There total 2 articles about ethyl (+/-)-2-oxo-2-(4-phenoxyphenyl)-1,3,2-oxazaphosphorinane-3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

N-(3-hydroxypropyl)glycine ethyl ester (118481-84-8) + 4-phenoxyphenylphosphonic dichloride (77918-50-4) → ethyl (+/-)-2-oxo-2-(4-phenoxyphenyl)-1,3,2-oxazaphosphorinane-3-acetate (391640-63-4)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2003.09.015

Reference yield:

diphenyl ether-4-phosphonic acid diethyl ester (77918-43-5) → ethyl (+/-)-2-oxo-2-(4-phenoxyphenyl)-1,3,2-oxazaphosphorinane-3-acetate (391640-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / PCl₅ / 110 - 120 °C

2: 44 percent / NMM / CH₂Cl₂ / 0 - 20 °C

With 4-methyl-morpholine; phosphorus pentachloride; In dichloromethane;

DOI:10.1016/j.bmc.2003.09.015

Reference yield: 39.0%

ethyl (+/-)-2-oxo-2-(4-phenoxyphenyl)-1,3,2-oxazaphosphorinane-3-acetate (391640-63-4) → (+/-)-2-Oxo-2-(4-phenoxyphenyl)-1,3,2-oxazaphosphorinane-3-acetohydroxamic acid

Guidance literature:

With O-Trimethylsilylhydroxylamine; sodium methylate; In methanol; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2003.09.015

upstream raw materials:

N-(3-hydroxypropyl)glycine ethyl ester

4-phenoxyphenylphosphonic dichloride

diphenyl ether-4-phosphonic acid diethyl ester

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