Technology Process of benzyl (2S,5S,6R,7R,8R,E)-6,7,9-tris(benzyloxy)-2-(tert-butoxycarbonylamino)-5,8-dihydroxynon-3-enoate
There total 2 articles about benzyl (2S,5S,6R,7R,8R,E)-6,7,9-tris(benzyloxy)-2-(tert-butoxycarbonylamino)-5,8-dihydroxynon-3-enoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
dichloromethane;
for 20h;
Heating;
DOI:10.1021/ol051341q
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 95 percent / tetrahydrofuran / 6 h / 20 °C
2: 62 percent / Grudds generation 2 catalyst / CH2Cl2 / 20 h / Heating
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
tetrahydrofuran; dichloromethane;
2: olefin cross-metathesis;
DOI:10.1021/ol051341q
- Guidance literature:
-
benzyl (2S,5S,6R,7R,8R,E)-6,7,9-tris(benzyloxy)-2-(tert-butoxycarbonylamino)-5,8-dihydroxynon-3-enoate;
With
mercury(II) trifluoroacetate;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
With
potassium chloride;
In
tetrahydrofuran; water;
at 20 ℃;
for 1h;
With
sodium tetrahydroborate; triethyl borane;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
DOI:10.1021/ol051341q
