(2S,3R)-3-[(S)-2-({(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid

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Chemical Name:(2S,3R)-3-[(S)-2-({(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid
CAS No.:327159-89-7
Molecular Formula:C₄₂H₅₆Cl₃N₅O₁₃
Molecular Weight:945.291
Hs Code.:

(2S,3R)-3-[(S)-2-({(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid

Synonyms:(2S,3R)-3-[(S)-2-({(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid

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Chemical Property of (2S,3R)-3-[(S)-2-({(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid

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Technology Process of (2S,3R)-3-[(S)-2-({(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid

There total 9 articles about (2S,3R)-3-[(S)-2-({(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 327159-88-6
3-[2-({1-[6-benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid 2-trimethylsilanyloxy-ethoxymethyl ester

: 327159-89-7
(2S,3R)-3-[(S)-2-({(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid

Guidance literature:: With magnesium bromide; In dichloromethane;
DOI:10.1016/S0960-894X(00)00585-0

Reference yield:

: 2592-18-9
Boc-Thr-OH

: 327159-89-7
(2S,3R)-3-[(S)-2-({(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / tetrahydrofuran

2: IPCF; Et₃N; DMAP / CH₂Cl₂

3: 100 percent / H₂ / 10 percent Pd/C / ethyl acetate; methanol

4: BOP-Cl; NMM

5: 96 percent / MgBr₂*Et₂O / CH₂Cl₂

With 4-methyl-morpholine; dmap; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; isopropyl chloroformate; triethylamine; magnesium bromide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0960-894X(00)00585-0

Reference yield:

: (2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-butyric acid 2-trimethylsilanyloxy-ethoxymethyl ester

: 327159-89-7
(2S,3R)-3-[(S)-2-({(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: IPCF; Et₃N; DMAP / CH₂Cl₂

2: 100 percent / H₂ / 10 percent Pd/C / ethyl acetate; methanol

3: BOP-Cl; NMM

4: 96 percent / MgBr₂*Et₂O / CH₂Cl₂

With 4-methyl-morpholine; dmap; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; isopropyl chloroformate; triethylamine; magnesium bromide; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0960-894X(00)00585-0