Technology Process of (2S,3R)-2-(tert-butyloxycarbonylamino)-3-hydroxy-1-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)pent-4-ene
There total 6 articles about (2S,3R)-2-(tert-butyloxycarbonylamino)-3-hydroxy-1-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)pent-4-ene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
DOI:10.1021/jm900290r
- Guidance literature:
-
Multi-step reaction with 2 steps
1: silver perchlorate; titanium tetrachloride / tetrahydrofuran; diethyl ether / 0.33 h / 0 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C
With
tetrabutyl ammonium fluoride; silver perchlorate; titanium tetrachloride;
In
tetrahydrofuran; diethyl ether;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tin(IV) chloride / benzene / 2 h / 20 °C / Heating / reflux
2.1: methanol; sodium methylate / 1 h
3.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C
3.2: 3 h / 20 °C
4.1: N-Bromosuccinimide; diethylamino-sulfur trifluoride / dichloromethane / 0.5 h / -15 °C
5.1: silver perchlorate; titanium tetrachloride / tetrahydrofuran; diethyl ether / 0.33 h / 0 °C
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C
With
methanol; N-Bromosuccinimide; diethylamino-sulfur trifluoride; tetrabutyl ammonium fluoride; sodium methylate; silver perchlorate; titanium tetrachloride; tin(IV) chloride; sodium hydride;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; benzene;
