(+/-)-3r-isopropyldimethylsiloxy-4t,5c-dimethoxy-6c-phthalimidocyclohexene

Base Information

• Chemical Name: (+/-)-3r-isopropyldimethylsiloxy-4t,5c-dimethoxy-6c-phthalimidocyclohexene
• CAS No.: 131244-21-8
• Molecular Formula: C₂₁H₂₉NO₅Si
• Molecular Weight: 403.55
• Mol file: 131244-21-8.mol

Synonyms:(+/-)-3r-isopropyldimethylsiloxy-4t,5c-dimethoxy-6c-phthalimidocyclohexene

Chemical Property of (+/-)-3r-isopropyldimethylsiloxy-4t,5c-dimethoxy-6c-phthalimidocyclohexene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-3r-isopropyldimethylsiloxy-4t,5c-dimethoxy-6c-phthalimidocyclohexene

There total 3 articles about (+/-)-3r-isopropyldimethylsiloxy-4t,5c-dimethoxy-6c-phthalimidocyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

isopropyldimethylsilyl chloride (3634-56-8) + (+/-)-5c,6t-dimethoxy-4c-phthalimidocyclohex-2-en-1r-ol (131244-19-4) → (+/-)-3r-isopropyldimethylsiloxy-4t,5c-dimethoxy-6c-phthalimidocyclohexene (131244-21-8)

Guidance literature:

With 1H-imidazole; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1039/P19900002255

Reference yield:

N-ethoxycarbonylphthalimide (22509-74-6) → (+/-)-3r-isopropyldimethylsiloxy-4t,5c-dimethoxy-6c-phthalimidocyclohexene (131244-21-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / Na₂CO₃ / acetone / 48 h / Ambient temperature

2: 95 percent / imidazole / CH₂Cl₂ / 4 h / Ambient temperature

With 1H-imidazole; sodium carbonate; In dichloromethane; acetone;

DOI:10.1039/P19900002255

Reference yield:

(1S,4R,5R,6R)-4-Amino-5,6-dimethoxy-cyclohex-2-enol (102698-40-8,109906-47-0) → (+/-)-3r-isopropyldimethylsiloxy-4t,5c-dimethoxy-6c-phthalimidocyclohexene (131244-21-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / Na₂CO₃ / acetone / 48 h / Ambient temperature

2: 95 percent / imidazole / CH₂Cl₂ / 4 h / Ambient temperature

With 1H-imidazole; sodium carbonate; In dichloromethane; acetone;

DOI:10.1039/P19900002255

upstream raw materials:

isopropyldimethylsilyl chloride

(+/-)-5c,6t-dimethoxy-4c-phthalimidocyclohex-2-en-1r-ol

N-ethoxycarbonylphthalimide

(1S,4R,5R,6R)-4-Amino-5,6-dimethoxy-cyclohex-2-enol

Downstream raw materials:

(+/-)-3t-hydroxy-4c,5t-dimethoxy-6t-phthalimido-2t-trichloroacetamidocyclohexyl acetate