3-(1-(dimethylsulfamoyl)-1H-imidazol-2-yl)-5-(5-((R)-2-teit-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-N-(methylsulfonyl)benzenamine

Base Information

Chemical Name:3-(1-(dimethylsulfamoyl)-1H-imidazol-2-yl)-5-(5-((R)-2-teit-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-N-(methylsulfonyl)benzenamine
CAS No.:868287-76-7
Molecular Formula:C₂₉H₃₇N₇O₇S₂
Molecular Weight:659.787
Hs Code.:

3-(1-(dimethylsulfamoyl)-1H-imidazol-2-yl)-5-(5-((R)-2-teit-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-N-(methylsulfonyl)benzenamine

Synonyms:3-(1-(dimethylsulfamoyl)-1H-imidazol-2-yl)-5-(5-((R)-2-teit-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-N-(methylsulfonyl)benzenamine

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Chemical Property of 3-(1-(dimethylsulfamoyl)-1H-imidazol-2-yl)-5-(5-((R)-2-teit-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-N-(methylsulfonyl)benzenamine

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Technology Process of 3-(1-(dimethylsulfamoyl)-1H-imidazol-2-yl)-5-(5-((R)-2-teit-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-N-(methylsulfonyl)benzenamine

There total 1 articles about 3-(1-(dimethylsulfamoyl)-1H-imidazol-2-yl)-5-(5-((R)-2-teit-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-N-(methylsulfonyl)benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 868286-55-9
tert-butyl [1-(5-{3-bromo-5-[methyl(methylsulfonyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)-(1R)-1-methyl-2-phenylethyl]carbamate

: 78162-58-0
N,N-dimethyl-1H-imidazole-1-sulfonamide

: 868287-76-7
3-(1-(dimethylsulfamoyl)-1H-imidazol-2-yl)-5-(5-((R)-2-teit-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-N-(methylsulfonyl)benzenamine

Guidance literature:: N,N-dimethyl-1H-imidazole-1-sulfonamide; With ethylmagnesium bromide; In tetrahydrofuran; hexanes; at -78 ℃; for 0.25h;

With zinc(II) chloride; In tetrahydrofuran; hexanes; at -78 - 20 ℃; for 1h;

tert-butyl [1-(5-{3-bromo-5-[methyl(methylsulfonyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)-(1R)-1-methyl-2-phenylethyl]carbamate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 80 ℃; for 0.75h; Microwave;

Reference yield:

: 868287-76-7
3-(1-(dimethylsulfamoyl)-1H-imidazol-2-yl)-5-(5-((R)-2-teit-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-N-(methylsulfonyl)benzenamine

: 76-05-1
trifluoroacetic acid

: 3-(5-((R)-2-amino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-5-(1H-imidazol-2-yl)-N-methyl-N-(methylsulfonyl)benzenamine trifluoroacetate

Guidance literature:: 3-(1-(dimethylsulfamoyl)-1H-imidazol-2-yl)-5-(5-((R)-2-teit-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-N-(methylsulfonyl)benzenamine; With hydrogenchloride; water; In acetonitrile; at 20 ℃; for 72h;

With sodium carbonate; In water;

trifluoroacetic acid;