4'-chloro-biphenyl-4-sulfonic acid (8-isopropoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide

Base Information

• Chemical Name: 4'-chloro-biphenyl-4-sulfonic acid (8-isopropoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide
• CAS No.: 583045-88-9
• Molecular Formula: C₂₅H₂₇ClN₂O₃S
• Molecular Weight: 471.02

Synonyms:4'-chloro-biphenyl-4-sulfonic acid (8-isopropoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide

Chemical Property of 4'-chloro-biphenyl-4-sulfonic acid (8-isopropoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide

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Technology Process of 4'-chloro-biphenyl-4-sulfonic acid (8-isopropoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide

There total 3 articles about 4'-chloro-biphenyl-4-sulfonic acid (8-isopropoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

7-(4'-chloro-biphenyl-4-sulfonylamino)-8-isopropoxy-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester (956141-98-3) → 4'-chloro-biphenyl-4-sulfonic acid (8-isopropoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide (583045-88-9)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2006.10.036

Reference yield:

7-amino-8-isopropoxy-1,2,4,5-tetrahydro-3-benzazepine-3-carboxylic acid tert-butyl ester (583047-12-5) → 4'-chloro-biphenyl-4-sulfonic acid (8-isopropoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide (583045-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

2: 78 percent / HCl / ethanol / 2 h / 20 °C

With pyridine; hydrogenchloride; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.10.036

Reference yield:

4'-chlorobiphenyl-4-sulfonyl chloride (20443-74-7) → 4'-chloro-biphenyl-4-sulfonic acid (8-isopropoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-amide (583045-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

2: 78 percent / HCl / ethanol / 2 h / 20 °C

With pyridine; hydrogenchloride; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.10.036

upstream raw materials:

7-(4'-chloro-biphenyl-4-sulfonylamino)-8-isopropoxy-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester

7-amino-8-isopropoxy-1,2,4,5-tetrahydro-3-benzazepine-3-carboxylic acid tert-butyl ester

4'-chlorobiphenyl-4-sulfonyl chloride

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