methyl (4βS,8αR)-4β-benzyl-7-oxo-4β,5,6,7,8,8α,9,10-octahydrophenanthrene-2-carboxylate

Base Information

Chemical Name:methyl (4βS,8αR)-4β-benzyl-7-oxo-4β,5,6,7,8,8α,9,10-octahydrophenanthrene-2-carboxylate
CAS No.:1044535-50-3
Molecular Formula:C₂₃H₂₄O₃
Molecular Weight:348.442
Hs Code.:

Synonyms:methyl (4βS,8αR)-4β-benzyl-7-oxo-4β,5,6,7,8,8α,9,10-octahydrophenanthrene-2-carboxylate

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Chemical Property of methyl (4βS,8αR)-4β-benzyl-7-oxo-4β,5,6,7,8,8α,9,10-octahydrophenanthrene-2-carboxylate

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Technology Process of methyl (4βS,8αR)-4β-benzyl-7-oxo-4β,5,6,7,8,8α,9,10-octahydrophenanthrene-2-carboxylate

There total 4 articles about methyl (4βS,8αR)-4β-benzyl-7-oxo-4β,5,6,7,8,8α,9,10-octahydrophenanthrene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1044535-48-9
methyl (4αS,8αR)-4β-benzyl-7,7-(1,2-ethylenedioxy)-4β,5,6,7,8,8α,9,10-octahydrophenanthrene-2-carboxylate

: 1044535-50-3
methyl (4βS,8αR)-4β-benzyl-7-oxo-4β,5,6,7,8,8α,9,10-octahydrophenanthrene-2-carboxylate

Guidance literature:: With water; trifluoroacetic acid; In dichloromethane; at 30 - 40 ℃; for 3.5h;

Reference yield: 89.0%

: 1400926-93-3
(S)-methyl 4b-benzyl-7-oxo-4b,5,6,7,9,10-hexahydrophenanthrene-2-carboxylate

: 1044535-50-3
methyl (4βS,8αR)-4β-benzyl-7-oxo-4β,5,6,7,8,8α,9,10-octahydrophenanthrene-2-carboxylate

Guidance literature:: (S)-methyl 4b-benzyl-7-oxo-4b,5,6,7,9,10-hexahydrophenanthrene-2-carboxylate; With (2R,5R)-5-benzyl-3-methyl-2-(5-methylfuran-2-yl)imidazolidin-4-one; trichloroacetic acid; In toluene; at 20 ℃; for 1h;

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; In toluene; for 96h;

Reference yield:

: 418772-23-3
(1R,9S,10R)-1-benzyl-5-bromo-10-hydroxy-10-methyl-tricyclo[7.3.1.0(2,7)]trideca-2,4,6-trien-13-one1(R)-benzyl-5-bromo-10(R)-hydroxy-10-methyl-tricyclo[7.3.1.0_2,7]trideca-2,4,6-trien-13-one

: 1044535-50-3
methyl (4βS,8αR)-4β-benzyl-7-oxo-4β,5,6,7,8,8α,9,10-octahydrophenanthrene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium ethanolate / ethanol / 0.5 h / 80 °C / Industry scale

2.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 15 h / 100 °C / 3102.97 Torr / Inert atmosphere

3.1: trichloroacetic acid; (2R,5R)-5-benzyl-3-methyl-2-(5-methylfuran-2-yl)imidazolidin-4-one / toluene / 1 h / 20 °C

3.2: 96 h

With (2R,5R)-5-benzyl-3-methyl-2-(5-methylfuran-2-yl)imidazolidin-4-one; sodium ethanolate; triethylamine; trichloroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In ethanol; toluene;