4-(((1R)-1-(1-fluorocyclopropyl)ethyl)amino)-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide

Base Information

Chemical Name:4-(((1R)-1-(1-fluorocyclopropyl)ethyl)amino)-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide
CAS No.:1400876-18-7
Molecular Formula:C₁₉H₁₉FN₄O
Molecular Weight:338.384
Hs Code.:

Synonyms:4-(((1R)-1-(1-fluorocyclopropyl)ethyl)amino)-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide

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Chemical Property of 4-(((1R)-1-(1-fluorocyclopropyl)ethyl)amino)-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide

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Technology Process of 4-(((1R)-1-(1-fluorocyclopropyl)ethyl)amino)-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide

There total 10 articles about 4-(((1R)-1-(1-fluorocyclopropyl)ethyl)amino)-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1400877-52-2
(R)-6-bromo-4-(1-(1-fluorocyclopropyl)ethylamino)pyrrolo[1,2-b]pyridazine-3-carboxamide

: 98-80-6
phenylboronic acid

: 1400876-18-7
4-(((1R)-1-(1-fluorocyclopropyl)ethyl)amino)-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide

Guidance literature:: With potassium phosphate; palladium diacetate; XPhos; In 1,4-dioxane; at 140 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 72652-32-5
1-(4-bromo-1H-pyrrol-2-yl)-2,2,2-trichloroethanone

: 1400876-18-7
4-(((1R)-1-(1-fluorocyclopropyl)ethyl)amino)-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium / 0.17 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 20 °C

2.3: 0.5 h

3.1: isopropyl alcohol / 3 h / 85 °C

3.2: 5 h / 85 °C

4.1: trichlorophosphate / dichloromethane / 3 h / 75 °C

4.2: 0 - 20 °C

5.1: sulfuric acid / 2 h / 55 °C

6.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C / Microwave irradiation

7.1: potassium phosphate / palladium diacetate; XPhos / 1,4-dioxane / 0.5 h / 140 °C / Microwave irradiation

With potassium phosphate; sulfuric acid; sodium; sodium hydride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium diacetate; XPhos; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

Reference yield:

: 934-05-4
methyl 4-bromo-1H-pyrrole-2-carboxylate

: 1400876-18-7
4-(((1R)-1-(1-fluorocyclopropyl)ethyl)amino)-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 20 °C / Inert atmosphere

1.2: 0.5 h / 20 °C

1.3: 0.5 h

2.1: isopropyl alcohol / 3 h / 85 °C

2.2: 5 h / 85 °C

3.1: trichlorophosphate / dichloromethane / 3 h / 75 °C

3.2: 0 - 20 °C

4.1: sulfuric acid / 2 h / 55 °C

5.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C / Microwave irradiation

6.1: potassium phosphate / palladium diacetate; XPhos / 1,4-dioxane / 0.5 h / 140 °C / Microwave irradiation

With potassium phosphate; sulfuric acid; sodium hydride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium diacetate; XPhos; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;