trans-1,3,4,5-tetrahydro-7-(phenylthio)-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Base Information

Chemical Name:trans-1,3,4,5-tetrahydro-7-(phenylthio)-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one
CAS No.:138335-06-5
Molecular Formula:C₂₃H₂₁NO₃S
Molecular Weight:391.491
Hs Code.:

Synonyms:trans-1,3,4,5-tetrahydro-7-(phenylthio)-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

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Chemical Property of trans-1,3,4,5-tetrahydro-7-(phenylthio)-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

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Technology Process of trans-1,3,4,5-tetrahydro-7-(phenylthio)-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

There total 16 articles about trans-1,3,4,5-tetrahydro-7-(phenylthio)-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 138335-67-8
1,3,4,5-tetrahydro-7-(phenylthio)-3-hydroxy-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

: 138335-06-5
trans-1,3,4,5-tetrahydro-7-(phenylthio)-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

: 138335-06-5
cis-1,3,4,5-tetrahydro-7-(phenylthio)-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Guidance literature:: With water; lithium iodide; In pyridine; for 1.5h; Title compound not separated from byproducts; Heating;
DOI:10.1021/jm00082a020

Reference yield: 46.0%

: 138335-67-8
1,3,4,5-tetrahydro-7-(phenylthio)-3-hydroxy-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

: 138335-06-5
trans-1,3,4,5-tetrahydro-7-(phenylthio)-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

: 138335-06-5
cis-1,3,4,5-tetrahydro-7-(phenylthio)-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Guidance literature:: With water; lithium iodide; In pyridine; for 1.5h; Title compound not separated from byproducts; Heating;
DOI:10.1021/jm00082a020

Reference yield:

: 5367-28-2
5-chloro-2-nitrotoluene

: 138335-06-5
trans-1,3,4,5-tetrahydro-7-(phenylthio)-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, 2.) DMF, RT, overnight

2: 67 percent / NaH / dimethylformamide / Ambient temperature

3: 85 percent / SnCl₂*2H₂O, conc. HCl / methanol / 4.5 h

4: 80 percent / CH₃ONa / methanol / 3 h / Heating

5: 1.) potassium hexamethyldisilazide, 2.) trimethylphosphite, O₂ / 1.) THF, -78 deg C, 1 h, 2.) THF, 0 deg C, 30 min

6: LiI, H₂O / pyridine / 1.5 h / Heating

With hydrogenchloride; water; oxygen; sodium methylate; potassium hexamethylsilazane; sodium hydride; tin(ll) chloride; lithium iodide; phosphorous acid trimethyl ester; In pyridine; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00082a020