2-Azabicyclo[2.2.1]heptane,3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-,(1S,3R,4R)-(9CI)

Base Information

Chemical Name:2-Azabicyclo[2.2.1]heptane,3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-,(1S,3R,4R)-(9CI)
CAS No.:700867-42-1
Molecular Formula:C₁₁H₁₈N₂O
Molecular Weight:194.277
Hs Code.:
Mol file:700867-42-1.mol

Synonyms:2-Azabicyclo[2.2.1]heptane,3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-,(1S,3R,4R)-(9CI)

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Chemical Property of 2-Azabicyclo[2.2.1]heptane,3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-,(1S,3R,4R)-(9CI)

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Technology Process of 2-Azabicyclo[2.2.1]heptane,3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-,(1S,3R,4R)-(9CI)

There total 4 articles about 2-Azabicyclo[2.2.1]heptane,3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-,(1S,3R,4R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 700867-41-0
(1S,3R,4R)-3-(4',5'-dihydro-5',5'-dimethyl-1',3'-oxazol-2'-yl)-2-aza-bicyclo-[2.2.1]-heptane-2-N-carboxylic acid p-nitrobenzyl ester

: 700867-42-1
(1S,3R,4R)-3-(4',5'-dihydro-5',5'-dimethyl-1',3'-oxazol-2'-yl)-2-aza-bicyclo-[2.2.1]-heptane

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; under 760.051 Torr;
DOI:10.1016/j.tet.2004.01.102

Reference yield:

: 171754-03-3,171754-02-2
(1S,3R,4R)-2-aza-bicyclo-[2.2.1]-heptane-3-carboxylic acid

: 700867-42-1
(1S,3R,4R)-3-(4',5'-dihydro-5',5'-dimethyl-1',3'-oxazol-2'-yl)-2-aza-bicyclo-[2.2.1]-heptane

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / NaOH / H₂O; dioxane / 20 °C

2: 72 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide; 1-hydroxybenzotriazole / CH₂Cl₂ / 0 - 20 °C

3: 74 percent / Et₃N; CH₃SO₂Cl / CH₂Cl₂ / 0 - 20 °C

4: 59 percent / H₂ / Pd/C / ethanol / 20 °C / 760.05 Torr

With sodium hydroxide; hydrogen; benzotriazol-1-ol; methanesulfonyl chloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; water;
DOI:10.1016/j.tet.2004.01.102

Reference yield:

: 700867-39-6
(1S,3S,4R)-2-aza-bicyclo-[2.2.1]-heptane-2,3-dicarboxylic acid 2-p-nitrobenzyl ester

: 700867-42-1
(1S,3R,4R)-3-(4',5'-dihydro-5',5'-dimethyl-1',3'-oxazol-2'-yl)-2-aza-bicyclo-[2.2.1]-heptane

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide; 1-hydroxybenzotriazole / CH₂Cl₂ / 0 - 20 °C

2: 74 percent / Et₃N; CH₃SO₂Cl / CH₂Cl₂ / 0 - 20 °C

3: 59 percent / H₂ / Pd/C / ethanol / 20 °C / 760.05 Torr

With hydrogen; benzotriazol-1-ol; methanesulfonyl chloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/j.tet.2004.01.102