4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methylthiophene-2-boronic acid

Base Information

Chemical Name:4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methylthiophene-2-boronic acid
CAS No.:1313189-35-3
Molecular Formula:C₂₃H₂₈BBrO₃SSi
Molecular Weight:503.34
Hs Code.:

Synonyms:4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methylthiophene-2-boronic acid

Suppliers and Price of 4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methylthiophene-2-boronic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methylthiophene-2-boronic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methylthiophene-2-boronic acid

There total 7 articles about 4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methylthiophene-2-boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29421-92-9
4-bromo-2-methylthiophene

: 1313189-35-3
4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methylthiophene-2-boronic acid

: C₄₆H₅₄B₂Br₂O₅S₂Si₂

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.05 h / -78 °C / Inert atmosphere

1.3: 1 h / -78 °C / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3.1: bromine; potassium acetate; acetic acid / 0 - 20 °C / Inert atmosphere

4.1: n-butyllithium / diethyl ether; hexane / 1 h / -78 °C / Inert atmosphere

4.2: 2.17 h / -78 - 20 °C / Inert atmosphere

4.3: 0 °C

With 1H-imidazole; n-butyllithium; bromine; potassium acetate; acetic acid; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/ejoc.201100166

Reference yield:

: 1313189-34-2
3-[2-(tert-butyldiphenylsilyloxy)ethyl]-2,4-dibromo-5-methylthiophene

: 1313189-35-3
4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methylthiophene-2-boronic acid

: C₄₆H₅₄B₂Br₂O₅S₂Si₂

Guidance literature:: 3-[2-(tert-butyldiphenylsilyloxy)ethyl]-2,4-dibromo-5-methylthiophene; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 1h; Inert atmosphere;

With Triisopropyl borate; In diethyl ether; hexane; at -78 - 20 ℃; for 2.16667h; Inert atmosphere;

With water; citric acid; at 0 ℃;
DOI:10.1002/ejoc.201100166

Reference yield:

: 554-14-3
2-Methylthiophene

: 1313189-35-3
4-bromo-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-5-methylthiophene-2-boronic acid

: C₄₆H₅₄B₂Br₂O₅S₂Si₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide; perchloric acid / N,N-dimethyl-formamide / 50 h / 20 °C / Inert atmosphere

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.05 h / -78 °C / Inert atmosphere

3.3: 1 h / -78 °C / Inert atmosphere

4.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

5.1: bromine; potassium acetate; acetic acid / 0 - 20 °C / Inert atmosphere

6.1: n-butyllithium / diethyl ether; hexane / 1 h / -78 °C / Inert atmosphere

6.2: 2.17 h / -78 - 20 °C / Inert atmosphere

6.3: 0 °C

With 1H-imidazole; N-Bromosuccinimide; n-butyllithium; perchloric acid; bromine; potassium acetate; acetic acid; diisopropylamine; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/ejoc.201100166