Trichloro-acetic acid (1R,3S,4R,4aR,9aR)-1-hydroxymethyl-6,6,8,8-tetraisopropyl-3-phenylsulfanyl-tetrahydro-2,5,7,9-tetraoxa-6,8-disila-benzocyclohepten-4-yl ester

Base Information

Chemical Name:Trichloro-acetic acid (1R,3S,4R,4aR,9aR)-1-hydroxymethyl-6,6,8,8-tetraisopropyl-3-phenylsulfanyl-tetrahydro-2,5,7,9-tetraoxa-6,8-disila-benzocyclohepten-4-yl ester
CAS No.:252001-15-3
Molecular Formula:C₂₆H₄₁Cl₃O₇SSi₂
Molecular Weight:660.203
Hs Code.:

Trichloro-acetic acid (1R,3S,4R,4aR,9aR)-1-hydroxymethyl-6,6,8,8-tetraisopropyl-3-phenylsulfanyl-tetrahydro-2,5,7,9-tetraoxa-6,8-disila-benzocyclohepten-4-yl ester

Synonyms:Trichloro-acetic acid (1R,3S,4R,4aR,9aR)-1-hydroxymethyl-6,6,8,8-tetraisopropyl-3-phenylsulfanyl-tetrahydro-2,5,7,9-tetraoxa-6,8-disila-benzocyclohepten-4-yl ester

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Chemical Property of Trichloro-acetic acid (1R,3S,4R,4aR,9aR)-1-hydroxymethyl-6,6,8,8-tetraisopropyl-3-phenylsulfanyl-tetrahydro-2,5,7,9-tetraoxa-6,8-disila-benzocyclohepten-4-yl ester

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Technology Process of Trichloro-acetic acid (1R,3S,4R,4aR,9aR)-1-hydroxymethyl-6,6,8,8-tetraisopropyl-3-phenylsulfanyl-tetrahydro-2,5,7,9-tetraoxa-6,8-disila-benzocyclohepten-4-yl ester

There total 5 articles about Trichloro-acetic acid (1R,3S,4R,4aR,9aR)-1-hydroxymethyl-6,6,8,8-tetraisopropyl-3-phenylsulfanyl-tetrahydro-2,5,7,9-tetraoxa-6,8-disila-benzocyclohepten-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Trichloro-acetic acid (1R,3S,4R,4aR,9aR)-6,6,8,8-tetraisopropyl-3-phenylsulfanyl-1-trityloxymethyl-tetrahydro-2,5,7,9-tetraoxa-6,8-disila-benzocyclohepten-4-yl ester

: 252001-15-3
Trichloro-acetic acid (1R,3S,4R,4aR,9aR)-1-hydroxymethyl-6,6,8,8-tetraisopropyl-3-phenylsulfanyl-tetrahydro-2,5,7,9-tetraoxa-6,8-disila-benzocyclohepten-4-yl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ja992608h

Reference yield:

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 252001-15-3
Trichloro-acetic acid (1R,3S,4R,4aR,9aR)-1-hydroxymethyl-6,6,8,8-tetraisopropyl-3-phenylsulfanyl-tetrahydro-2,5,7,9-tetraoxa-6,8-disila-benzocyclohepten-4-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine

1.2: 59 percent / p-TsOH / dimethylformamide

2.1: pyridine

4.1: TFA / CH₂Cl₂

With pyridine; trifluoroacetic acid; In dichloromethane; 1.1: silylation / 1.2: Isomerization / 2.1: Etherification / 3.1: Acetylation / 4.1: deprotection;
DOI:10.1021/ja992608h

Reference yield:

: 2936-70-1,5624-48-6,13992-15-9,16758-34-2,28244-97-5,77481-62-0,77481-63-1,105088-17-3,149495-84-1
(2R,3S,4S,5R,6S)-2-Hydroxymethyl-6-phenylsulfanyl-tetrahydro-pyran-3,4,5-triol

: 252001-15-3
Trichloro-acetic acid (1R,3S,4R,4aR,9aR)-1-hydroxymethyl-6,6,8,8-tetraisopropyl-3-phenylsulfanyl-tetrahydro-2,5,7,9-tetraoxa-6,8-disila-benzocyclohepten-4-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine

1.2: 59 percent / p-TsOH / dimethylformamide

2.1: pyridine

4.1: TFA / CH₂Cl₂

With pyridine; trifluoroacetic acid; In dichloromethane; 1.1: silylation / 1.2: Isomerization / 2.1: Etherification / 3.1: Acetylation / 4.1: deprotection;
DOI:10.1021/ja992608h