(2S,3S)-(-)-2,3-BUTANEDIOL DI-P-TOSYLATE

Base Information

• Chemical Name: (2S,3S)-(-)-2,3-BUTANEDIOL DI-P-TOSYLATE
• CAS No.: 74839-83-1
• Molecular Formula: C18H22 O6 S2
• Molecular Weight: 398.49
• Mol file: 74839-83-1.mol

Synonyms:2,3-Butanediol,bis(4-methylbenzenesulfonate), [S-(R*,R*)]- (9CI)

Chemical Property of (2S,3S)-(-)-2,3-BUTANEDIOL DI-P-TOSYLATE

Chemical Property:

• Vapor Pressure: 1.37E-11mmHg at 25°C
• Melting Point: 67-69 °C(lit.)
• Refractive Index: 1.554
• Boiling Point: 550.2°C at 760 mmHg
• Flash Point: 286.5°C
• PSA: 103.50000
• Density: 1.273g/cm³
• LogP: 5.35280

Purity/Quality:

(2S,3S)-(-)-2,3-Butanedioldi-p-tosylate 98% ^*data from reagent suppliers

Safty Information:

• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S,3S)-(-)-2,3-BUTANEDIOL DI-P-TOSYLATE

There total 6 articles about (2S,3S)-(-)-2,3-BUTANEDIOL DI-P-TOSYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(2S,3S)-butane-2,3-diol (19132-06-0) + p-toluenesulfonyl chloride (98-59-9) → (2S,3S)-bis(4-methylbenzenesulfonyl)butane (74839-83-1)

Guidance literature:

In pyridine; 1.) 0 deg C, 30 min, 2.) room temp., 15 h;

Reference yield: 55.0%

(R,R)-2,3-butandiol (24347-58-8) + p-toluenesulfonyl chloride (98-59-9) → (+/-)-2,3-butanediol di-p-tosylate (49662-27-3,64896-27-1,74839-83-1,90026-01-0,90026-02-1) + (-)-(1R,2R)-2-hydroxy-1-methylpropyl p-toluenesulfonate

Guidance literature:

In pyridine; for 23h; Ambient temperature;

DOI:10.1002/hlca.19840670324

Reference yield:

d,l-2,3-butanediol (6982-25-8) + p-toluenesulfonyl chloride (98-59-9) → (+/-)-2,3-butanediol di-p-tosylate (49662-27-3,64896-27-1,74839-83-1,90026-01-0,90026-02-1)

Guidance literature:

With pyridine;

DOI:10.1021/ja01213a017

upstream raw materials:

d,l-2,3-butanediol

p-toluenesulfonyl chloride

(R,R)-2,3-butandiol

(2S,3S)-butane-2,3-diol

Downstream raw materials:

(R,R)-chiraphos

(2R,3R)-bis(2-iodo-3-nitrophenoxyl)butane