(4-{4-amino-7-[2-(aminomethyl)-1,3-thiazol-4-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2,6-difluorophenyl)methanol

Base Information

Chemical Name:(4-{4-amino-7-[2-(aminomethyl)-1,3-thiazol-4-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2,6-difluorophenyl)methanol
CAS No.:1417736-32-3
Molecular Formula:C₁₇H₁₄F₂N₆OS
Molecular Weight:388.401
Hs Code.:

Synonyms:(4-{4-amino-7-[2-(aminomethyl)-1,3-thiazol-4-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2,6-difluorophenyl)methanol

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Chemical Property of (4-{4-amino-7-[2-(aminomethyl)-1,3-thiazol-4-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2,6-difluorophenyl)methanol

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Technology Process of (4-{4-amino-7-[2-(aminomethyl)-1,3-thiazol-4-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2,6-difluorophenyl)methanol

There total 3 articles about (4-{4-amino-7-[2-(aminomethyl)-1,3-thiazol-4-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2,6-difluorophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1417736-43-6
[2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol

: 1417736-88-9
tert-butyl {[4-(4-amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-7-yl)-1,3-thiazol-2-yl]methyl}carbamate

: 1417736-32-3
(4-{4-amino-7-[2-(aminomethyl)-1,3-thiazol-4-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2,6-difluorophenyl)methanol

Guidance literature:: [2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol; tert-butyl {[4-(4-amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-7-yl)-1,3-thiazol-2-yl]methyl}carbamate; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 140 ℃; for 3h; Inert atmosphere; Microwave irradiation;

With trifluoroacetic acid; In dichloromethane; for 0.333333h;

With sodium carbonate; In water;

Reference yield:

: 162744-59-4
(4-bromo-2,6-difluoro-phenyl)methanol

: 1417736-32-3
(4-{4-amino-7-[2-(aminomethyl)-1,3-thiazol-4-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2,6-difluorophenyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 1 h / 130 °C / Inert atmosphere; Microwave irradiation

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 3 h / 140 °C / Inert atmosphere; Microwave irradiation

2.2: 0.33 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; In 1,4-dioxane; water;

Reference yield:

: 937047-27-3
1-(4-amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-chloroethanone

: 1417736-32-3
(4-{4-amino-7-[2-(aminomethyl)-1,3-thiazol-4-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}-2,6-difluorophenyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 20 h / Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 3 h / 140 °C / Inert atmosphere; Microwave irradiation

2.2: 0.33 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; ethanol; water;