4-Chlorothieno[2,3-B]pyridine-5-carboxylic acid

Base Information

Chemical Name:4-Chlorothieno[2,3-B]pyridine-5-carboxylic acid
CAS No.:700844-19-5
Molecular Formula:C₈H₄ClNO₂S
Molecular Weight:213.644
Hs Code.:
DSSTox Substance ID:DTXSID20463375
Wikidata:Q82288238
Mol file:700844-19-5.mol

Synonyms:4-CHLOROTHIENO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID;700844-19-5;4-Chlorothieno[2,3-b]pyridine-5-carboxylicacid;SCHEMBL4904903;DTXSID20463375;SRFCCWMMWYCDSK-UHFFFAOYSA-N

Suppliers and Price of 4-Chlorothieno[2,3-B]pyridine-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-CHLOROTHIENO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID 95.00%
5MG
$ 500.20

Total 4 raw suppliers

Chemical Property of 4-Chlorothieno[2,3-B]pyridine-5-carboxylic acid

Chemical Property:

PSA：78.43000
LogP:2.64790
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:212.9651272
Heavy Atom Count:13
Complexity:226

Purity/Quality:

95% ^*data from raw suppliers

4-CHLOROTHIENO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CSC2=NC=C(C(=C21)Cl)C(=O)O

Technology Process of 4-Chlorothieno[2,3-B]pyridine-5-carboxylic acid

There total 1 articles about 4-Chlorothieno[2,3-B]pyridine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59713-58-5
ethyl 4-chlorothieno<2,3-b>pyridine-5-carboxylate

: 700844-19-5
4-chlorothieno[3,2-b]pyridine-5-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 1.5h; Heating;
DOI:10.1021/jm049237m

Reference yield:

: 700844-19-5
4-chlorothieno[3,2-b]pyridine-5-carboxylic acid

: 700844-39-9
4-[(2,4-dichloro-5-methoxyphenyl)amino]-2-iodothieno[3,2-b]pyridine-5-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 2 h / Heating

2.1: 175 mg / aq. ammonia / acetone / 2 h / 0 °C

3.1: 84 mg / cyanuric chloride / dimethylformamide / 0.5 h / 20 °C

4.1: LDA / heptane; tetrahydrofuran; ethylbenzene / 0.58 h / -78 °C

4.2: 1.0 g / iodine / tetrahydrofuran; heptane; ethylbenzene / 4 h / -78 °C

5.1: NaH / tetrahydrofuran / 1 h / Heating

5.2: 0.28 g / tetrahydrofuran / 5 h / Heating

With ammonium hydroxide; thionyl chloride; 1,3,5-trichloro-2,4,6-triazine; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm049237m

Reference yield:

: 700844-19-5
4-chlorothieno[3,2-b]pyridine-5-carboxylic acid

: 700844-59-3
4-[(2,4-dichloro-5-methoxyphenyl)amino]-2-(4-formylphenyl)thieno[3,2-b]pyridine-5-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 2 h / Heating

2.1: 175 mg / aq. ammonia / acetone / 2 h / 0 °C

3.1: 84 mg / cyanuric chloride / dimethylformamide / 0.5 h / 20 °C

4.1: LDA / heptane; tetrahydrofuran; ethylbenzene / 0.58 h / -78 °C

4.2: 1.0 g / iodine / tetrahydrofuran; heptane; ethylbenzene / 4 h / -78 °C

5.1: NaH / tetrahydrofuran / 1 h / Heating

5.2: 0.28 g / tetrahydrofuran / 5 h / Heating

6.1: 0.16 g / (PPh₃)4Pd; aq. NaHCO₃ / 1,2-dimethoxy-ethane / 1 h / Heating

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; 1,3,5-trichloro-2,4,6-triazine; sodium hydride; sodium hydrogencarbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; n-heptane; ethylbenzene; N,N-dimethyl-formamide; acetone; 6.1: Suzuki reaction;
DOI:10.1021/jm049237m