4-Chlorothieno[2,3-B]pyridine-5-carboxylic acid

Base Information

• Chemical Name: 4-Chlorothieno[2,3-B]pyridine-5-carboxylic acid
• CAS No.: 700844-19-5
• Molecular Formula: C₈H₄ClNO₂S
• Molecular Weight: 213.644
• DSSTox Substance ID: DTXSID20463375
• Wikidata: Q82288238
• Mol file: 700844-19-5.mol

Synonyms:4-CHLOROTHIENO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID;700844-19-5;4-Chlorothieno[2,3-b]pyridine-5-carboxylicacid;SCHEMBL4904903;DTXSID20463375;SRFCCWMMWYCDSK-UHFFFAOYSA-N

Chemical Property of 4-Chlorothieno[2,3-B]pyridine-5-carboxylic acid

Chemical Property:

• PSA: 78.43000
• LogP: 2.64790
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 212.9651272
• Heavy Atom Count: 13
• Complexity: 226

Purity/Quality:

95% ^*data from raw suppliers

4-CHLOROTHIENO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC2=NC=C(C(=C21)Cl)C(=O)O

Technology Process of 4-Chlorothieno[2,3-B]pyridine-5-carboxylic acid

There total 1 articles about 4-Chlorothieno[2,3-B]pyridine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-chlorothieno<2,3-b>pyridine-5-carboxylate (59713-58-5) → 4-chlorothieno[3,2-b]pyridine-5-carboxylic acid (700844-19-5)

Guidance literature:

With sodium hydroxide; In ethanol; for 1.5h; Heating;

DOI:10.1021/jm049237m

Reference yield:

4-chlorothieno[3,2-b]pyridine-5-carboxylic acid (700844-19-5) → 4-[(2,4-dichloro-5-methoxyphenyl)amino]-2-iodothieno[3,2-b]pyridine-5-carbonitrile (700844-39-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: thionyl chloride / 2 h / Heating

2.1: 175 mg / aq. ammonia / acetone / 2 h / 0 °C

3.1: 84 mg / cyanuric chloride / dimethylformamide / 0.5 h / 20 °C

4.1: LDA / heptane; tetrahydrofuran; ethylbenzene / 0.58 h / -78 °C

4.2: 1.0 g / iodine / tetrahydrofuran; heptane; ethylbenzene / 4 h / -78 °C

5.1: NaH / tetrahydrofuran / 1 h / Heating

5.2: 0.28 g / tetrahydrofuran / 5 h / Heating

With ammonium hydroxide; thionyl chloride; 1,3,5-trichloro-2,4,6-triazine; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm049237m

Reference yield:

4-chlorothieno[3,2-b]pyridine-5-carboxylic acid (700844-19-5) → 4-[(2,4-dichloro-5-methoxyphenyl)amino]-2-(4-formylphenyl)thieno[3,2-b]pyridine-5-carbonitrile (700844-59-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: thionyl chloride / 2 h / Heating

2.1: 175 mg / aq. ammonia / acetone / 2 h / 0 °C

3.1: 84 mg / cyanuric chloride / dimethylformamide / 0.5 h / 20 °C

4.1: LDA / heptane; tetrahydrofuran; ethylbenzene / 0.58 h / -78 °C

4.2: 1.0 g / iodine / tetrahydrofuran; heptane; ethylbenzene / 4 h / -78 °C

5.1: NaH / tetrahydrofuran / 1 h / Heating

5.2: 0.28 g / tetrahydrofuran / 5 h / Heating

6.1: 0.16 g / (PPh₃)4Pd; aq. NaHCO₃ / 1,2-dimethoxy-ethane / 1 h / Heating

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; 1,3,5-trichloro-2,4,6-triazine; sodium hydride; sodium hydrogencarbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; n-heptane; ethylbenzene; N,N-dimethyl-formamide; acetone; 6.1: Suzuki reaction;

DOI:10.1021/jm049237m

upstream raw materials:

ethyl 4-chlorothieno<2,3-b>pyridine-5-carboxylate

Downstream raw materials:

4-chloro-5-cyanothieno<2,3-b>pyridine

4-chlorothieno[3,2-b]pyridine-5-carboxamide

4-chloro-2-iodothieno[3,2-b]pyridine-5-carbonitrile

4-[(2,4-dichloro-5-methoxyphenyl)amino]-2-iodothieno[3,2-b]pyridine-5-carbonitrile