ethyl 3-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}sulfonyl)propanoate

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Chemical Name:ethyl 3-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}sulfonyl)propanoate
CAS No.:1114591-57-9
Molecular Formula:C₂₄H₃₂N₄O₅S
Molecular Weight:488.608
Hs Code.:

Synonyms:ethyl 3-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}sulfonyl)propanoate

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Chemical Property of ethyl 3-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}sulfonyl)propanoate

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Technology Process of ethyl 3-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}sulfonyl)propanoate

There total 9 articles about ethyl 3-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}sulfonyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1114592-34-5
ethyl 3-(4-aminobenzylsulfonyl)propanoate

: 1114592-17-4
6-[(cyclopropylmethyl)(propyl)amino]pyrimidine-4-carboxylic acid

: 1114591-57-9
ethyl 3-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}sulfonyl)propanoate

Guidance literature:: 6-[(cyclopropylmethyl)(propyl)amino]pyrimidine-4-carboxylic acid; With triethylamine; methyl chloroformate; In dichloromethane; at 0 ℃; for 0.5h;

ethyl 3-(4-aminobenzylsulfonyl)propanoate; In dichloromethane; at 0 - 20 ℃; for 1.08333h;

Reference yield:

: 5466-06-8
3-mercaptopropionic acid ethyl ester

: 1114591-57-9
ethyl 3-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}sulfonyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 18 h / 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 72 h / 20 °C

3.1: hydrogen / 5%-palladium/activated carbon / ethanol; ethyl acetate / 5 h

4.1: triethylamine; methyl chloroformate / dichloromethane / 0.5 h / 0 °C

4.2: 1.08 h / 0 - 20 °C

With hydrogen; potassium carbonate; triethylamine; methyl chloroformate; 3-chloro-benzenecarboperoxoic acid; 5%-palladium/activated carbon; In ethanol; dichloromethane; ethyl acetate; acetone;

Reference yield:

: 1114592-32-3
ethyl 3-(4-nitrobenzylthio)propanoate

: 1114591-57-9
ethyl 3-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]benzyl}sulfonyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 72 h / 20 °C

2.1: hydrogen / 5%-palladium/activated carbon / ethanol; ethyl acetate / 5 h

3.1: triethylamine; methyl chloroformate / dichloromethane / 0.5 h / 0 °C

3.2: 1.08 h / 0 - 20 °C

With hydrogen; triethylamine; methyl chloroformate; 3-chloro-benzenecarboperoxoic acid; 5%-palladium/activated carbon; In ethanol; dichloromethane; ethyl acetate;