1,1,1,3,3,3-hexafluoro-2-[4-(5-hydroxymethyl-2-isopropyl-imidazol-1-yl)-phenyl]-propan-2-ol

Base Information

• Chemical Name: 1,1,1,3,3,3-hexafluoro-2-[4-(5-hydroxymethyl-2-isopropyl-imidazol-1-yl)-phenyl]-propan-2-ol
• CAS No.: 876143-01-0
• Molecular Formula: C₁₆H₁₆F₆N₂O₂
• Molecular Weight: 382.306

Synonyms:1,1,1,3,3,3-hexafluoro-2-[4-(5-hydroxymethyl-2-isopropyl-imidazol-1-yl)-phenyl]-propan-2-ol

Chemical Property of 1,1,1,3,3,3-hexafluoro-2-[4-(5-hydroxymethyl-2-isopropyl-imidazol-1-yl)-phenyl]-propan-2-ol

Chemical Property:

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Technology Process of 1,1,1,3,3,3-hexafluoro-2-[4-(5-hydroxymethyl-2-isopropyl-imidazol-1-yl)-phenyl]-propan-2-ol

There total 3 articles about 1,1,1,3,3,3-hexafluoro-2-[4-(5-hydroxymethyl-2-isopropyl-imidazol-1-yl)-phenyl]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-isopropyl-3-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-3H-imidazole-4-carbaldehyde (444622-08-6) → 1,1,1,3,3,3-hexafluoro-2-[4-(5-hydroxymethyl-2-isopropyl-imidazol-1-yl)-phenyl]-propan-2-ol (876143-01-0)

Guidance literature:

With sodium tetrahydroborate; In methanol;

DOI:10.1016/j.bmcl.2005.10.020

Reference yield:

N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-isobutyramidine (876143-22-5) → 1,1,1,3,3,3-hexafluoro-2-[4-(5-hydroxymethyl-2-isopropyl-imidazol-1-yl)-phenyl]-propan-2-ol (876143-01-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. K₂CO₃ / CHCl₃

2: 100 percent / NaBH₄ / methanol

With sodium tetrahydroborate; potassium carbonate; In methanol; chloroform;

DOI:10.1016/j.bmcl.2005.10.020

Reference yield:

2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol (722-92-9) → 1,1,1,3,3,3-hexafluoro-2-[4-(5-hydroxymethyl-2-isopropyl-imidazol-1-yl)-phenyl]-propan-2-ol (876143-01-0)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. K₂CO₃ / CHCl₃

2: 100 percent / NaBH₄ / methanol

With sodium tetrahydroborate; potassium carbonate; In methanol; chloroform;

DOI:10.1016/j.bmcl.2005.10.020

upstream raw materials:

2-isopropyl-3-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-3H-imidazole-4-carbaldehyde

N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-isobutyramidine

2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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