2-(2-aminobenzoylamino)-3-p-tolylpropionic acid ethyl ester

Base Information

• Chemical Name: 2-(2-aminobenzoylamino)-3-p-tolylpropionic acid ethyl ester
• CAS No.: 856571-05-6
• Molecular Formula: C₁₉H₂₂N₂O₃
• Molecular Weight: 326.395
• Mol file: 856571-05-6.mol

Synonyms:2-(2-aminobenzoylamino)-3-p-tolylpropionic acid ethyl ester

Chemical Property of 2-(2-aminobenzoylamino)-3-p-tolylpropionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(2-aminobenzoylamino)-3-p-tolylpropionic acid ethyl ester

There total 3 articles about 2-(2-aminobenzoylamino)-3-p-tolylpropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-amino-3-p-tolylpropionic acid ethyl ester hydrochloride + isatoic anhydride (118-48-9) → 2-(2-aminobenzoylamino)-3-p-tolylpropionic acid ethyl ester (856571-05-6)

Guidance literature:

With triethylamine; In ethyl acetate; for 4h; Heating;

DOI:10.1016/j.ejmech.2005.01.002

Reference yield:

2-amino-3-p-tolylpropionic acid hydrochloride (4313-79-5) → 2-(2-aminobenzoylamino)-3-p-tolylpropionic acid ethyl ester (856571-05-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / HCl / 0 °C

2: 55 percent / Et₃N / ethyl acetate / 4 h / Heating

With hydrogenchloride; triethylamine; In ethyl acetate;

DOI:10.1016/j.ejmech.2005.01.002

Reference yield:

2-acetylamino-2-(4-methylbenzyl)malonic acid diethyl ester (82291-79-0) → 2-(2-aminobenzoylamino)-3-p-tolylpropionic acid ethyl ester (856571-05-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / HCl / H₂O; dioxane / Heating

2: 87 percent / HCl / 0 °C

3: 55 percent / Et₃N / ethyl acetate / 4 h / Heating

With hydrogenchloride; triethylamine; In 1,4-dioxane; water; ethyl acetate;

DOI:10.1016/j.ejmech.2005.01.002

upstream raw materials:

isatoic anhydride

2-amino-3-p-tolylpropionic acid hydrochloride

2-acetylamino-2-(4-methylbenzyl)malonic acid diethyl ester

Downstream raw materials:

2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-3-p-tolylpropionic acid ethyl ester