C₁₈H₁₁ClF₂N₆O

Base Information

Chemical Name:C₁₈H₁₁ClF₂N₆O
CAS No.:1190722-48-5
Molecular Formula:C₁₈H₁₁ClF₂N₆O
Molecular Weight:400.775
Hs Code.:

C<sub>18</sub>H<sub>11</sub>ClF<sub>2</sub>N<sub>6</sub>O

Synonyms:C₁₈H₁₁ClF₂N₆O

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Chemical Property of C₁₈H₁₁ClF₂N₆O

Chemical Property:

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Technology Process of C₁₈H₁₁ClF₂N₆O

There total 9 articles about C₁₈H₁₁ClF₂N₆O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1190735-62-6
C₁₈H₁₀ClF₂N₃O

: 1190722-48-5
C₁₈H₁₁ClF₂N₆O

Guidance literature:: C₁₈H₁₀ClF₂N₃O; With azido tributyltin (IV); In toluene; for 8h; Reflux;

With hydrogenchloride; In water; toluene; for 1h; Reflux;

Reference yield:

: 110888-15-8
4-chloro-3-fluorobenzonitrile

: 1190722-48-5
C₁₈H₁₁ClF₂N₆O

Guidance literature:: Multi-step reaction with 9 steps

1.1: trimethylaluminum; ammonium chloride / toluene / 80 °C / Inert atmosphere

2.1: sodium ethanolate / ethanol / 3 h / Reflux

3.1: trichlorophosphate / N,N-dimethyl-aniline / 22 h / Reflux

4.1: sodium hydride / tetrahydrofuran / -78 - 20 °C

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 2 h / Reflux; Inert atmosphere

6.1: water; sodium hydroxide / ethanol / 20 °C

7.1: oxalyl dichloride; N,N-dimethyl-formamide / chloroform / 1 h / 20 °C

7.2: 1 h / 20 °C

8.1: pyridine; trifluoroacetic anhydride / chloroform / 1.5 h / 20 °C

9.1: azido tributyltin (IV) / toluene / 8 h / Reflux

9.2: 1 h / Reflux

With pyridine; oxalyl dichloride; water; trimethylaluminum; sodium ethanolate; sodium hydride; sodium carbonate; ammonium chloride; N,N-dimethyl-formamide; azido tributyltin (IV); trifluoroacetic anhydride; sodium hydroxide; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; chloroform; water; N,N-dimethyl-aniline; toluene;

Reference yield:

: 1190735-16-0
4-chloro-3-fluorobenzamidine hydrochloride

: 1190722-48-5
C₁₈H₁₁ClF₂N₆O

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium ethanolate / ethanol / 3 h / Reflux

2.1: trichlorophosphate / N,N-dimethyl-aniline / 22 h / Reflux

3.1: sodium hydride / tetrahydrofuran / -78 - 20 °C

4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 2 h / Reflux; Inert atmosphere

5.1: water; sodium hydroxide / ethanol / 20 °C

6.1: oxalyl dichloride; N,N-dimethyl-formamide / chloroform / 1 h / 20 °C

6.2: 1 h / 20 °C

7.1: pyridine; trifluoroacetic anhydride / chloroform / 1.5 h / 20 °C

8.1: azido tributyltin (IV) / toluene / 8 h / Reflux

8.2: 1 h / Reflux

With pyridine; oxalyl dichloride; water; sodium ethanolate; sodium hydride; sodium carbonate; N,N-dimethyl-formamide; azido tributyltin (IV); trifluoroacetic anhydride; sodium hydroxide; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; chloroform; water; N,N-dimethyl-aniline; toluene;