{2-[(4'-chloro-6-methyl-biphenyl-2-carbonyl)-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-yl}-carbamic acid methyl ester

Base Information

Chemical Name:{2-[(4'-chloro-6-methyl-biphenyl-2-carbonyl)-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-yl}-carbamic acid methyl ester
CAS No.:391655-51-9
Molecular Formula:C₂₇H₂₇ClN₂O₃
Molecular Weight:462.976
Hs Code.:

{2-[(4'-chloro-6-methyl-biphenyl-2-carbonyl)-amino]-6,7,8,9-tetrahydro-5<i>H</i>-benzocyclohepten-7-yl}-carbamic acid methyl ester

Synonyms:{2-[(4'-chloro-6-methyl-biphenyl-2-carbonyl)-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-yl}-carbamic acid methyl ester

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Chemical Property of {2-[(4'-chloro-6-methyl-biphenyl-2-carbonyl)-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-yl}-carbamic acid methyl ester

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Technology Process of {2-[(4'-chloro-6-methyl-biphenyl-2-carbonyl)-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-yl}-carbamic acid methyl ester

There total 9 articles about {2-[(4'-chloro-6-methyl-biphenyl-2-carbonyl)-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-yl}-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37949-03-4
5,6,8,9-tetrahydrobenzo[7]annulen-7-one

: 391655-51-9
{2-[(4'-chloro-6-methyl-biphenyl-2-carbonyl)-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-yl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 56 percent / NH₂OH*HCl; aq. Na₂CO₃

2: NaBH₄; TiCl₄ / dimethylformamide

3: iPr₂NEt / CH₂Cl₂ / 1 h

4: fuming HNO₃; CF₃COOH / 3 h / 0 °C

5: H₂ / 10percent Pd/C / ethyl acetate / 16 h / 20 °C / 2585.81 Torr

6: pyridine / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; sodium tetrahydroborate; hydroxylamine hydrochloride; hydrogen; nitric acid; titanium tetrachloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 10percent Pd/C; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm010294e

Reference yield:

: 92367-49-2
hydroxylamine, N-(6,7,8,9-tetrahydro-5H-benzo[a]cyclohepten-7-yl)-

: 391655-51-9
{2-[(4'-chloro-6-methyl-biphenyl-2-carbonyl)-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-yl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄; TiCl₄ / dimethylformamide

2: iPr₂NEt / CH₂Cl₂ / 1 h

3: fuming HNO₃; CF₃COOH / 3 h / 0 °C

4: H₂ / 10percent Pd/C / ethyl acetate / 16 h / 20 °C / 2585.81 Torr

5: pyridine / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; sodium tetrahydroborate; hydrogen; nitric acid; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 10percent Pd/C; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm010294e

Reference yield:

: 450-60-2
5H-benzo[a]cyclohepten-7-amine, 6,7,8,9-tetrahydro-

: 391655-51-9
{2-[(4'-chloro-6-methyl-biphenyl-2-carbonyl)-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-7-yl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: iPr₂NEt / CH₂Cl₂ / 1 h

2: fuming HNO₃; CF₃COOH / 3 h / 0 °C

3: H₂ / 10percent Pd/C / ethyl acetate / 16 h / 20 °C / 2585.81 Torr

4: pyridine / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; hydrogen; nitric acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 10percent Pd/C; In dichloromethane; ethyl acetate;
DOI:10.1021/jm010294e