NADPH-D

Base Information

• Chemical Name: NADPH-D
• CAS No.: 74784-45-5
• Molecular Formula: C₂₁H₃₀N₇O₁₇P₃
• Molecular Weight: 746.419
• Mol file: 74784-45-5.mol

Synonyms:NADPH-D;74784-45-5;?-NADPH-D

Chemical Property of NADPH-D

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.849
• Boiling Point: 1175.129°C at 760 mmHg
• Flash Point: 664.494°C
• PSA: 393.58000
• Density: 2.287g/cm³
• LogP: -1.35000
• Storage Temp.: -20°C
• XLogP3: -6.8
• Hydrogen Bond Donor Count: 9
• Hydrogen Bond Acceptor Count: 22
• Rotatable Bond Count: 13
• Exact Mass: 746.09738025
• Heavy Atom Count: 48
• Complexity: 1410

Purity/Quality:

97% ^*data from raw suppliers

NADPH-D 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)(O)O)O)O)O
• Isomeric SMILES: [2H]C1C=CN(C=C1C(=O)N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)OP(=O)(O)O)O)O)O
• Uses: One of the biologically active forms of nicotinic acid. Differs from NAD by an additional phosphate group at the 2’-position of the adenosine moiety. Serves as a coenzyme of hydrogenases and dehydrogenases. Present in living cells primarily in the reduced form (NADPH) and is involved in synthetic reactions.

Technology Process of NADPH-D

There total 10 articles about NADPH-D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

d8-isopropanol (22739-76-0) + nicotinamide adenine dinucleotide phosphate (604-79-5) → (4R)-[2H]NADPH (74784-45-5,94859-57-1,80443-35-2)

Guidance literature:

In water; at 40 ℃; tris-HCl-buffer (pH 7.8), alcohol dehydrogenase from T_. brockii;

Reference yield: 67.0%

NADP (53-59-8) → (4R)-[2H]NADPH (74784-45-5,94859-57-1,80443-35-2)

Guidance literature:

With d8-isopropanol; Thermoanaerobium brockii alcohol dehydrogenase; at 43 ℃; pH=9.0; aq. buffer; Enzymatic reaction;

Reference yield: 62.5%

NADP (53-59-8) → (4S)-[2H]NADPH (74784-45-5)

Guidance literature:

With (1-²H)-D-glucose; glucose-L-dehydrogenase from Pseudomonas sp.; Enzymatic reaction;

DOI:10.1002/jlcr.3419

upstream raw materials:

d8-isopropanol

nicotinamide adenine dinucleotide phosphate

<4-(2)H>-NADP

nicotinamide adenine dinucleotide