(1R,4S,6S)-6-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxodeca-2,4,8-trien-2-yl>-6-hydroxy-4-methoxy-3-methylcyclohex-2-enecarboxylic acid

Base Information

Chemical Name:(1R,4S,6S)-6-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxodeca-2,4,8-trien-2-yl>-6-hydroxy-4-methoxy-3-methylcyclohex-2-enecarboxylic acid
CAS No.:129245-54-1
Molecular Formula:C₃₅H₅₄O₉
Molecular Weight:618.808
Hs Code.:

(1R,4S,6S)-6-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxodeca-2,4,8-trien-2-yl>-6-hydroxy-4-methoxy-3-methylcyclohex-2-enecarboxylic acid

Synonyms:(1R,4S,6S)-6-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxodeca-2,4,8-trien-2-yl>-6-hydroxy-4-methoxy-3-methylcyclohex-2-enecarboxylic acid

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Chemical Property of (1R,4S,6S)-6-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxodeca-2,4,8-trien-2-yl>-6-hydroxy-4-methoxy-3-methylcyclohex-2-enecarboxylic acid

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Technology Process of (1R,4S,6S)-6-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxodeca-2,4,8-trien-2-yl>-6-hydroxy-4-methoxy-3-methylcyclohex-2-enecarboxylic acid

There total 23 articles about (1R,4S,6S)-6-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxodeca-2,4,8-trien-2-yl>-6-hydroxy-4-methoxy-3-methylcyclohex-2-enecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 129245-53-0
Methyl (6R,2Z,4E,8E)-6,8-dimethyl-2-<(1S,2R,5S)-1-hydroxy-5-methoxy-4-methyl-2-(2-trimethylsilylethoxycarbonyl)cyclohex-3-en-1-yl>-10-<(2R,4S,6R,8R,9S)-4-tert-butyldimethylsilyloxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-deca-2,4,8-trie...

: 129245-54-1
(1R,4S,6S)-6-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxodeca-2,4,8-trien-2-yl>-6-hydroxy-4-methoxy-3-methylcyclohex-2-enecarboxylic acid

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 10h; Ambient temperature;
DOI:10.1039/a605894i

Reference yield:

: 129245-45-0
(1R,4S,6S)-6-Hydroxy-4-methoxy-3-methyl-6-(2-trimethylsilyl-3-furyl)cyclohex-2-enecarboxylic acid

: 129245-54-1
(1R,4S,6S)-6-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxodeca-2,4,8-trien-2-yl>-6-hydroxy-4-methoxy-3-methylcyclohex-2-enecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / DMAP, DCC / CH₂Cl₂ / 16 h / Ambient temperature

2: 95 percent / O₂, tetraphenylporphyrin / CH₂Cl₂; methanol / 0.33 h / -78 °C / Irradiation

3: lithium hexamethyldisilazide / tetrahydrofuran / 1.) -78 deg C to -15 deg C, 1 h, 2.) -15 deg C, 1 h

4: 2.) I₂ / 1.) ether, 2.) C₆H₆, 8 h, sunlight

5: 100 percent / TBAF / tetrahydrofuran / 10 h / Ambient temperature

With dmap; tetrabutyl ammonium fluoride; iodine; oxygen; 5,15,10,20-tetraphenylporphyrin; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/a605894i

Reference yield:

: 129285-24-1
2-Trimethylsilyl (1R,4S,6S)-6-hydroxy-4-methoxy-3-methyl-6-(2-trimethylsilyl-3-furyl)cyclohex-2-enecarboxylate

: 129245-54-1
(1R,4S,6S)-6-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxodeca-2,4,8-trien-2-yl>-6-hydroxy-4-methoxy-3-methylcyclohex-2-enecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / O₂, tetraphenylporphyrin / CH₂Cl₂; methanol / 0.33 h / -78 °C / Irradiation

2: lithium hexamethyldisilazide / tetrahydrofuran / 1.) -78 deg C to -15 deg C, 1 h, 2.) -15 deg C, 1 h

3: 2.) I₂ / 1.) ether, 2.) C₆H₆, 8 h, sunlight

4: 100 percent / TBAF / tetrahydrofuran / 10 h / Ambient temperature

With tetrabutyl ammonium fluoride; iodine; oxygen; 5,15,10,20-tetraphenylporphyrin; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/a605894i