1-Azabicyclo[2.2.1]heptane,2,4,6-trimethyl-,(2R,6S)-rel-(9CI)

Base Information

• Chemical Name: 1-Azabicyclo[2.2.1]heptane,2,4,6-trimethyl-,(2R,6S)-rel-(9CI)
• CAS No.: 700378-37-6
• Molecular Formula: C₉H₁₇N
• Molecular Weight: 139.241
• Mol file: 700378-37-6.mol

Synonyms:1-Azabicyclo[2.2.1]heptane,2,4,6-trimethyl-,(2R,6S)-rel-(9CI)

Chemical Property of 1-Azabicyclo[2.2.1]heptane,2,4,6-trimethyl-,(2R,6S)-rel-(9CI)

Chemical Property:

• PSA: 3.24000
• LogP: 1.81700

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Azabicyclo[2.2.1]heptane,2,4,6-trimethyl-,(2R,6S)-rel-(9CI)

There total 12 articles about 1-Azabicyclo[2.2.1]heptane,2,4,6-trimethyl-,(2R,6S)-rel-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

2-allyl-2-methylpent-4-enylamine → 2,4,6-trimethyl-1-aza-bicyclo[2.2.1]heptane (700378-36-5,700378-28-5,700378-37-6) + (2S,4R)-4-allyl-2,4-dimethylpyrrolidine + (2R,4R)-4-allyl-2,4-dimethylpyrrolidine

Guidance literature:

With [Mg{η⁵-C₅H₃-1,3-(CH₂CH₂NiPr₂)(SiMe₂NPh₂)}][BPh₄]; In benzene-d6; at 120 ℃; for 20h; Reagent/catalyst; Time; Catalytic behavior; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1039/c5cy01040c

Reference yield:

2-allyl-2-methylpent-4-en-1-amine (39074-87-8) → 2,4,6-trimethyl-1-aza-bicyclo[2.2.1]heptane (700378-36-5,700378-28-5,700378-37-6)

Guidance literature:

With C₃₂H₁₂BF₂₄^(1-)*C₄₁H₄₄NOSZr⁽¹⁺⁾; In d5-bromobenzene; at 130 ℃; for 144h;

DOI:10.1021/ol201731m

Reference yield:

2-allyl-2-methylpent-4-en-1-amine (39074-87-8) → 2,4,6-trimethyl-1-aza-bicyclo[2.2.1]heptane (700378-28-5,700378-37-6) + 2,4,6-trimethyl-1-aza-bicyclo[2.2.1]heptane (700378-37-6)

Guidance literature:

With n-butyllithium; In hexane; toluene; at 90 ℃; for 16h; Title compound not separated from byproducts.;

DOI:10.1016/j.tet.2007.11.066

upstream raw materials:

4-allyl-2,4-dimethyl-pyrrolidine

2-allyl-2-methylpent-4-en-1-amine