N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-pyrrolidinyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Base Information

Chemical Name:N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-pyrrolidinyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide
CAS No.:1195768-09-2
Molecular Formula:C₂₃H₁₈ClF₂N₅O₂S₂
Molecular Weight:534.01
Hs Code.:

Synonyms:N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-pyrrolidinyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

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Chemical Property of N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-pyrrolidinyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

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Technology Process of N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-pyrrolidinyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

There total 4 articles about N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-pyrrolidinyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 40398-36-5
pyrrolidine-1-carbothioic acid amide

: 1195768-08-1
N-{3-[(Z)-2-(2-Chloro-4-pyrimidinyl)-1-hydroxyethenyl]-phenyl}-2,6-difluorobenzenesulfonamide

: 1195768-09-2
N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-pyrrolidinyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Guidance literature:: N-{3-[(Z)-2-(2-Chloro-4-pyrimidinyl)-1-hydroxyethenyl]-phenyl}-2,6-difluorobenzenesulfonamide; With N-Bromosuccinimide; In dichloromethane; at 20 ℃; Inert atmosphere;

pyrrolidine-1-carbothioic acid amide; With magnesium carbonate; In 1,4-dioxane; for 3h;

Reference yield:

: 1195768-07-0
ethyl 3-{[(2,6-difluorophenyl)sulfonyl]amino}benzoate

: 1195768-09-2
N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-pyrrolidinyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0 °C

1.2: 0 - 20 °C

2.1: N-Bromosuccinimide / dichloromethane

With N-Bromosuccinimide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

Reference yield:

: 582-33-2
3-aminobenzoic acid ethyl ester

: 1195768-09-2
N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-pyrrolidinyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0 °C

2.2: 0 - 20 °C

3.1: N-Bromosuccinimide / dichloromethane

With pyridine; N-Bromosuccinimide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;